Chloramphenicol
Synonymous: levamycin
Chemical formula: C11H12Cl2N2O5
Molecular weight: 323.14
CAS : 56-75-7
EINECS No.: 200-287-4
Melting Point; 148 to 150 ℃
Boiling Point: 563.2 ℃
Water solubility: slightly soluble
Dense Degree: 1.474 g / cm ³
Appearance: white to off white crystalline powder
Flash Point: 294.4 ℃
Category: bacteriostatic broad-spectrum antibiotics
Malpractice End: serious adverse reactions in hematopoietic system
Uses: block protein synthesis
Product introduction:
Chloramphenicol is an antibiotic K .It is easily soluble in methanol, ethanol, propanol and ethyl acetate y, slightly soluble in ether and chloroform, and insoluble in petroleum ether and benzene. Chloramphenicol is extremely stable, and its aqueous solution will not fail after boiling for 5h. Because there are two asymmetric carbon atoms in chloramphenicol molecule, chloramphenicol has four optical isomers, of which only the left-handed isomer has antibacterial ability.
Chloramphenicol is a broad spectrum antibiotic introduced into clinical practice in 1948, but which was subsequently shown to cause serious and fatal aplastic anemia and is now used rarely and reserved for severe, life-threatening infections for which other antibiotics are not available. Chloramphenicol has also been linked to cases of acute, clinically apparent liver injury with jaundice, largely in association with aplastic anemia.
IUPAC
2,2-dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide
SMILES
C1=CC(=CC=C1[C@H]([C@@H](CO)NC(=O)C(Cl)Cl)O)[N+](=O)[O-]