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Zhejiang Pure Pharmaceutical Co.,Ltd.

15 YRS

Zhejiang, China

CNY 76.9 Million

99900 m²

100-500 people

Main Products: Dexamethasone Sodium Phosphate / Abiraterone / Eplerenone / Hydroxyprogesterone / 21-Deacetoxy Deflazacort / Cortisol / Flumethasone / Fluticasone Propionate / Dehydroepiandrosterone

Zhejiang, China

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Abiraterone / CAS 154229-19-3

OVERVIEW

Packaging

25 KG/Fibre Drum

Lead Time

14-30 days

Max Capacity

30 MT/Year

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DESCRIPTION

Abiraterone, with the molecular formula c24h31no, is a CYP17 inhibitor that is primarily indicated clinically in combination with prednisone for the treatment of patients with metastatic castration refractory prostate cancer who have previously received docetaxel containing chemotherapy.

Typical Properties

Abiraterone acetate (INN, USAN, BAN, JAN) (brand names Zytiga, Abiratas, Abretone, Abirapro) is a steroidal antiandrogen, specifically an androgen synthesis inhibitor, used in combination with prednisone in metastatic castration-resistant prostate cancer (previously called hormone-resistant or hormone-refractory prostate cancer) – i.e., prostate cancer not responding to androgen deprivation or treatment with androgen receptor antagonists. It is a prodrug to the active agent abiraterone, and is marketed by Janssen Biotech under the trade name Zytiga. In addition, Intas Pharmaceuticals markets the drug under the trade name Abiratas, Cadila Pharmaceuticals markets the drug as Abretone, and Glenmark Pharmaceuticals as Abirapro. Abiraterone acetate was approved by the United States Food and Drug Administration on April 28, 2011. The FDA press release made reference to a phase III clinical trial in which abiraterone use was associated with a median survival of 14.8 months versus 10.9 months with placebo; the study was stopped early because of the successful outcome.

CAS No.

154229-19-3

Formula

C24H31NO

Molecular Mass

349.50900

Exact Mass

349.24100

PSA

33.12000

Logp

5.39860

IUPAC

(3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-pyridin-3-yl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-ol

SMILES

C[C@]12CC[C@@H](CC1=CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC=C4C5=CN=CC=C5)C)O

Matter Classification

organic

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