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Tipr Pharmaceutical Co.,Ltd.
Tipr Pharmaceutical Co.,Ltd.
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Tianjin, China
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Tianjin, China
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Glibenclamide / CAS 10238-21-8
OVERVIEW
Packaging
10 KG/Fibre Drum
Lead Time
14-30 days
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DESCRIPTION
Glibenclamide
【Chemical Name】5-chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxy benzamide
【CAS Number】10238-21-8
【Molecular Formula】C23H28ClN3O5S
【Molecular Weight】494.00
【Content】≥99.0%
【Therap-Cat】Hypoglycemic
【Package】10kg/drum
【Specification】CP2005
Typical Properties
Summary
Glibenclamide, also known as youjiangtang and daantai, belongs to the second generation of oral sulfonylurea hypoglycemic drugs. Its action mechanism is the same as tolbutamide. Its hypoglycemic effect is the strongest among sulfonylureas, and its action intensity is 200 ~ 250 times that of tolbutamide. It can selectively act on the pancreas β Cells and promote the secretion of insulin, which can enhance the hypoglycemic effect of exogenous insulin and strengthen the post receptor effect of insulin. Oral absorption is fast and the protein binding rate is high. The effect begins when the chemical book is opened in 30 minutes, and the effect is the strongest in 1.5 hours, lasting for 16 ~ 24 hours. The distribution volume is 0.1l/kg, the plasma protein binding rate is 90% ~ 95%, and the half-life is 4 ~ 8 hours. It is mainly metabolized by the liver. There are six metabolites, two of which are known to be hydroxylates, which have no hypoglycemic effect. They are mainly discharged from the urine and a small amount from the stool. Clinically, it is mainly used to treat mild to moderate non-insulin-dependent diabetes mellitus.
CAS No.
10238-21-8
Formula
C23H28ClN3O5S
Molecular Mass
494.00400
Exact Mass
493.14400
PSA
121.98000
Logp
5.89520
IUPAC
5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide
SMILES
COC1=C(C=C(C=C1)Cl)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3
Attribute classification
Category
Other Chemicals
Auxiliary > Other Auxiliary Agent
API & Intermediate > Hormones And Endocrine Drugs
Auxiliary > Other Auxiliary Agent
API & Intermediate > Hormones And Endocrine Drugs
Chemical and Physical Properties
Melting Point
173-175°C
Density
1.36 g/cm3
Appearance
white or almost white crystalline powder
Export information
HS Code
2935900090
Export Rebate
13%
UN No.
0.0
DG-Class
0.0
Risk Code
R20/21/22
Safety Label
Xn
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