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Changzhou Lanxing Chemical Co.,Ltd.
Changzhou Lanxing Chemical Co.,Ltd.
22 YRS
Jiangsu, China
Main Products:
Potassium Thioacetate / Thioacetic Acid / Loperamide Hydrochloride / 1-Hydroxybenzotriazole / 3-Methyl-2-Nitrobenzoic Acid
Jiangsu, China
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1-Hydroxybenzotriazole / CAS 2592-95-2
OVERVIEW
Packaging
25 KG/Fibre Drum
Lead Time
14-30 days
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DESCRIPTION
1-Hydroxybenzotriazole
CAS:34552-83-5
Molecular formula：C6H5N3O
Molecular weight：135.12300
Appearance:White to off-white crystalline powder.
Purpose：Hydroxybenzotriazole (HOBt), white crystal, 1n hydroxyl substituted derivative of benzotriazole. It is often used as racemization inhibitor in peptide synthesis. When DCC dehydration condensation is used to prepare peptides in the classical method, the chiral center of the substrate can not be well maintained in the product due to the high activity of DCC. Generally, additives such as hydroxybenzotriazole are added to reduce the activity of activated esters to inhibit racemization. See details See peptide synthesis. Hydroxybenzotriazole is usually sold as monohydrate crystal (~ 11.7% water, weight). Anhydrous hydroxybenzotriazole is explosive and should be paid attention to when used.
Structural formula:
Typical Properties
Summary
Hydroxybenzotriazole (HOBt), white crystal, 1n hydroxyl substituted derivative of benzotriazole. It is often used as racemization inhibitor in peptide synthesis. When DCC dehydration condensation is used to prepare peptides in the classical method, the chiral center of the substrate can not be well maintained in the product due to the high activity of DCC. Generally, additives such as hydroxybenzotriazole are added to reduce the activity of activated esters to inhibit racemization. See details See peptide synthesis. Hydroxybenzotriazole is usually sold as monohydrate crystal (~ 11.7% water, weight). Anhydrous hydroxybenzotriazole is explosive and should be paid attention to when used.
CAS No.
2592-95-2
Formula
C6H5N3O
Molecular Mass
135.12300
Exact Mass
135.04300
PSA
61.80000
Logp
0.66350
IUPAC
1-hydroxybenzotriazole
SMILES
C1=CC=C2C(=C1)N=NN2O
Attribute classification
Matter Classification
organic
Category
Auxiliary > Other Auxiliary Agent
Chemical and Physical Properties
Melting Point
156-159°C
Density
1 g/cm3
Boiling Point
149-150 °C
Flash Point
95 °C
Appearance
White to off-white crystalline powder.
Export information
HS Code
29339900
Export Rebate
13%
UN No.
1325
Risk Code
R11; R5
Safety Label
F
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