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NINGBO TEAM PHARMACEUTICALS CO.,LTD
NINGBO TEAM PHARMACEUTICALS CO.,LTD
32 YRS
Zhejiang, China
Main Products:
Gemcitabine Hydrochloride / Ondansetron Hydrochloride / Granisetron Hydrochloride / Toremifene Citrate / Baclofen / Carvedilol / Doxofylline
Zhejiang, China
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Gemcitabine Hydrochloride / CAS 122111-03-9
OVERVIEW
Packaging
| Pallets Packing | 20'FCL | 40'FCL | ||
| With | Without | With | Without | |
|
25 KG/Fibre Drum
|
--
|
20 MT
|
--
|
20 MT
|
Lead Time
In Stock
Max Capacity
10 MT/Year
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Less than 1KG required
DESCRIPTION
Gemcitabine hydrochloride
Name in English: gemcitabinehydrochloride
CAS number: 122111-03-9
Molecular formula:C9H12ClF2N3O4
Structural formula:
MW: 299.66
EINECS number: 601-823-3
Purpose: it is indicated for the treatment of inoperable advanced or metastatic pancreatic cancer and for the treatment of locally progressive or metastatic non-small cell lung cancer, intermediate - and advanced non-small cell lung cancer, non-small cell lung cancer, pancreatic cancer, bladder cancer, breast cancer and other solid tumors.
Typical Properties
Summary
Gemcitabine hydrochloride is a synthetic new type of two fluoronucleoside antitumor drug developed by Eli Lilly. It was approved in 1995 in South Africa, Sweden, Holland, Australia and other countries. In 1996, the US Food and Drug Administration approved the first line treatment for non-small cell lung cancer and pancreatic cancer. Gemcitabine hydrochloride, a nucleoside homologue, is a cell cycle specific antitumor drug. It mainly kills cells in S phase (DNA synthesis) and blocks the transition of cell proliferation from G1 to S phase. Gemcitabine is suitable for the treatment of advanced or metastatic pancreatic cancer and locally advanced or metastatic non-small cell lung cancer, advanced and non-small cell lung cancer, pancreatic cancer, bladder cancer, breast cancer and other solid tumors.
CAS No.
122111-03-9
Formula
C9H12ClF2N3O4
Molecular Mass
299.65900
Exact Mass
299.04800
PSA
110.60000
Logp
0.09460
IUPAC
4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one;hydrochloride
SMILES
C1=CN(C(=O)N=C1N)[C@H]2C([C@@H]([C@H](O2)CO)O)(F)F.Cl
Attribute classification
Matter Classification
organic
Category
API & Intermediate > Antineoplastic Agents
Chemical and Physical Properties
Melting Point
>250°C dec.
Boiling Point
482.7ºC
Flash Point
245.7ºC
Appearance
White powder
Export information
HS Code
29349990
Export Rebate
10%
Export Formalities
Q
Risk Code
R21-36/38-46-62-63
Safety Label
Xn,Xi
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