On Chemball

My Chemball

As Supplier

My RFQ Manage Products

As Buyer

My RFQ Post RFQ

My Account

+86-571-8627 3270

NINGBO TEAM PHARMACEUTICALS CO.,LTD

32 YRS

Zhejiang, China

CNY 415 Million

127872 m²

100-500 people

Main Products: Gemcitabine Hydrochloride / Ondansetron Hydrochloride / Granisetron Hydrochloride / Toremifene Citrate / Baclofen / Carvedilol / Doxofylline

Zhejiang, China

Contact Supplier

Home Company Profile Contact Us Post Buying Request

Granisetron Hydrochloride / CAS 107007-99-8

OVERVIEW

Packaging

25 KG/Fibre Drum

Lead Time

14-30 days

REQUEST A QUOTATION

Submit

Get Free Samples

Less than 1KG required

DESCRIPTION

Granisetron hydrochloride

English Name: granisetron hydrochloride

CAS number: 107007-99-8

Molecular formula: C18H25ClN4O

Structural formula:

MW: 348.870

Uses: it is mainly used in radiotherapy, nausea and vomiting caused by cytotoxic chemotherapy.

Typical Properties

Granisetron hydrochloride is a highly selective 5-HT3 receptor antagonist, which has good preventive and therapeutic effects on nausea and vomiting caused by radiotherapy, chemotherapy and surgery. Radiotherapy, chemotherapy and surgery can cause the release of 5-HT from the intestinal chromaffin cells. 5-HT can activate the 5-HT3 receptor of the central or vagus nerve and cause vomiting reflex. The mechanism of controlling nausea and vomiting is to inhibit the occurrence of nausea and vomiting by antagonizing 5-HT3 receptors in central chemosensory area and peripheral vagus nerve endings. It has high selectivity and no side effects such as extrapyramidal reaction and excessive sedation.

CAS No.

107007-99-8

Formula

C18H25ClN4O

Molecular Mass

348.87000

Exact Mass

348.17200

PSA

50.16000

Logp

3.44920

IUPAC

1-methyl-N-(9-methyl-9-azabicyclo[3.3.1]nonan-3-yl)indazole-3-carboxamide;hydrochloride

SMILES

CN1C2CCCC1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C.Cl

Matter Classification

organic

GET SAMPLE