Benazepril Hydrochloride
Synonymous: | Lotensin |
CAS: | 86541-74-4 |
Molecular Formula: | C24H29ClN2O5 |
Molecular Weight: | 460.95 |
Appearance | Crystalline solid |
Storage | 2-8℃ |
Category | Drugs for treating hypertension |
Effect:
The main component of benazepril hydrochloride tablets is benazepril hydrochloride, which can be used in the adjuvant treatment of patients with hypertension, congestive heart failure and congestive heart failure with poor response to digitalis and / or diuretics. Its mechanism is that benazepril can inhibit the activity of angiotensin converting enzyme, so as to alleviate a series of symptoms caused by angiotensin (increased blood pressure, accelerated excitatory heart rate caused by vasodilation, insufficient cardiac output, etc.).
Indication:
Benazepril hydrochloride tablets are used for hypertension and congestive heart failure. (for the treatment of moderate and mild hypertension, the curative effect is the same as that of captopril, enalapril, nifedipine, nitrendipine, propranolol and other drugs. It is a second-line drug for the treatment of hypertension.) Benazepri1 Hydroch1oride Tab1ets is an angiotensin-converting enzyme inhibitor (ACEI). It is a new choice drug for the treatment of hypertension. It has definite curative effect, mild side effects, safe use of liver and kidney insufficiency, and it also has curative effect on heart disease, diabetes and kidney disease. This product is a national medical insurance class B product.
Mechanism of action:
Benner Pury * is an angiotensinconverting enzyme inhibitor, which can reduce the various effects mediated by angiotensin II, reduce peripheral vascular resistance and lower blood pressure, but does not cause compensatory fluid retention. It also reduces ventricular afterload and does not increase heart rate. It can improve left ventricular hypertrophy and improve glucose tolerance in diabetics. It can be used as an adjuvant therapy for patients with congestive heart failure with poor response to cardiac glycosides and diuretics.
Adverse reactions:
Benazepril hydrochloride tablet is an oral drug, It is recommended that patients who have not taken diuretics should take 10mg each time (one tablet), once a day, and can be appropriately increased to 2 tablets a day. The dose can be adjusted according to the data of blood pressure, generally once every 1-2 weeks. During the use, the patient may have headache, dizziness, palpitation, skin flushing, cough, upper respiratory tract infection symptoms, gastrointestinal dysfunction, etc. its tolerance is good, but if there is rare blood In case of symptoms such as small plate reduction, anemia and vascular edema, consult a doctor for treatment.
Matters needing attention:
Forbidden for pregnant women; It is not recommended for children and lactating women because of insufficient clinical data; Patients with cough, hyperkalemia, impaired renal function, surgery / anesthesia should be used with caution; Patients with hepatitis, liver failure, angioedema, symptomatic hypotension, allergic reaction, neutropenia / neutropenia and other symptoms during treatment need to stop this drug.
Purpose:
This product is used for hypertension and congestive heart failure.
The main component of benazepril hydrochloride tablets is benazepril hydrochloride, which can be used in the adjuvant treatment of patients with hypertension, congestive heart failure and congestive heart failure with poor response to digitalis and / or diuretics. Its mechanism is that benazepril can inhibit the activity of angiotensin converting enzyme, so as to alleviate a series of symptoms caused by angiotensin (increased blood pressure, accelerated excitatory heart rate caused by vasodilation, insufficient cardiac output, etc.).
IUPAC
2-[(3S)-3-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-2-oxo-4,5-dihydro-3H-1-benzazepin-1-yl]acetic acid;hydrochloride
SMILES
CCOC(=O)C(CCC1=CC=CC=C1)NC2CCC3=CC=CC=C3N(C2=O)CC(=O)O.Cl