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Shanghai Bocimed Pharmaceutical Co.,Ltd.
Shanghai Bocimed Pharmaceutical Co.,Ltd.
12 YRS
Shanghai, China
Main Products:
Relugolix / Carfilzomib / Ixazomib Citrate / Apalutamide / Avatrombopag / Fulvestrant / Lenvatinib Mesylate / Ruxolitinib Phosphate / Roxadustat / Brivaracetam
Shanghai, China
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Roxadustat / CAS 808118-40-3
OVERVIEW
Packaging
25 KG/Fibre Drum
Lead Time
14-30 days
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DESCRIPTION
Roxadustat
CAS:808118-40-3
Molecular formula: C19H16N2O5
Molecular weight: 352.34100
Introduction: Roxadustat is a novel hypoxia-inducible factor (HIF)-prolyl hydroxylase (PH) enzyme inhibitor. It stabilizes HIF, inhibits its degradation, activates the transcription of related genes, and produces corresponding physiological responses , moderately increase the concentration of erythropoietin, improve the sensitivity of erythropoietin (EPO) receptors, coordinate the production of red blood cells, reduce the level of hepcidin, increase the content and activity of transferrin receptors, and promote the absorption and utilization of iron, And well tolerated.
Structural formula:
Typical Properties
Summary
Roxastat is a new hypoxia inducible factor (HIF) - prolyl hydroxylase (PH) enzyme inhibitor. It can stabilize HIF, inhibit its degradation, activate the transcription of related genes, produce corresponding physiological responses, moderately increase the concentration of erythropoietin and improve erythropoietin (EPO) receptor sensitivity, coordinate the production of erythrocytes, reduce the level of ferritin, increase the content and activity of transferrin receptor, promote the absorption and utilization of iron, and it is well tolerated.
CAS No.
808118-40-3
Formula
C19H16N2O5
Molecular Mass
352.34
Exact Mass
352.10600
PSA
108.75000
Logp
3.24640
IUPAC
2-[(4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carbonyl)amino]acetic acid
SMILES
CC1=C2C=C(C=CC2=C(C(=N1)C(=O)NCC(=O)O)O)OC3=CC=CC=C3
Attribute classification
Matter Classification
organic
Category
API & Intermediate > Blood System Drugs
Chemical and Physical Properties
Density
1.389 g/cm3
Boiling Point
684.3±55.0 °C(Predicted)
Flash Point
367.6ºC
Export information
HS Code
0.0
UN No.
0.0
DG-Class
0.0
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