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Shandong Holly Pharmaceutical Co., Ltd.
Shandong Holly Pharmaceutical Co., Ltd.
31 YRS
Shandong, China
Main Products:
Veratraldehyde / 1,2-Dimethoxybenzene / 3,4-Dimethoxybenzoic Acid / Isovanillin / 1-Adamantanamine Hydrochloride / 2-Amino-6-Methoxybenzothiazole / 4,5-Dimethoxy-2-Nitrobenzaldehyde
Shandong, China
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1-Adamantanamine Hydrochloride / CAS 665-66-7
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DESCRIPTION
1-Adamantanamine hydrochloride | |
Synonymy | AMANTADINE HCL |
CAS # | 665-66-7 |
Structural Formula |
|
Appearance | Crystalline Solid |
Assay | ≥99.0% |
Melting Point | 300℃ |
Water | ≤0.5% |
Package | 25Kg/cardboard drum |
Typical Properties
Summary
Amantadine Hydrochloride is the hydrochloride salt of amantadine, a synthetic tricyclic amine with antiviral, antiparkinsonian, and antihyperalgesic activities. Amantadine appears to exert its antiviral effect against the influenza A virus by interfering with the function of the transmembrane domain of the viral M2 protein, thereby preventing the release of infectious viral nucleic acids into host cells; furthermore, this agent prevents virus assembly during virus replication. Amantadine exerts its antiparkinsonian effects by stimulating the release of dopamine from striatal dopaminergic nerve terminals and inhibiting its pre-synaptic reuptake. This agent may also exert some anticholinergic effect through inhibition of N-methyl-D-aspartic acid (NMDA) receptor-mediated stimulation of acetylcholine, resulting in antihyperalgesia.
CAS No.
665-66-7
Formula
C10H18ClN
Molecular Mass
187.71000
Exact Mass
187.11300
PSA
26.02000
Logp
3.41620
IUPAC
adamantan-1-amine;hydrochloride
SMILES
C1C2CC3CC1CC(C2)(C3)N.Cl
Attribute classification
Matter Classification
organic
Category
API & Intermediate > Nervous System Drugs
Chemical and Physical Properties
Melting Point
>300 °C
Density
1.067g/cm3
Boiling Point
225.7ºC
Flash Point
96ºC
Appearance
White crystalline powder.
Export information
HS Code
29213000
Export Rebate
13%
Risk Code
R22-40-20/21/22
Safety Label
Xn
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