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Taicang Qianjing Chemical.,Ltd.
Taicang Qianjing Chemical.,Ltd.
20 YRS
Jiangsu, China
Main Products:
4,6-Dichloro-5-(2-Methoxyphenoxy)-2,2'-Bipyrimidine / 5-(2-Methoxyphenoxy)-[2,2'-Bipyrimidine]-4,6(1H,5H)-Dione / Pyrimidine-2 Carboxamidine HCl / 2-Cyanopyrimidine / 3-(Aminomethyl)-5-Methylhexanoic Acid / 3-Isobutylpiperidine-2,6-Dione / 3-(2-Amino-2-Oxoethyl)-5-Methylhexanoic Acid / 3-Isobutylglutaric Acid / (S)-3-Tert-Butylamino-1,2-Propanediol / 3-Chloro-4-Morpholino-1,2,5-Thiadiazole / 3,4-Dichloro-1,2,5-Thiadiazole / 3,3-Tetramethyleneglutarimide / Calcium Phosphorylcholine Chloride
Jiangsu, China
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4,6-Dichloro-5-(2-Methoxyphenoxy)-2,2'-Bipyrimidine
5-(2-Methoxyphenoxy)-[2,2'-Bipyrimidine]-4,6(1H,5H)-Dione
2-Amidinopyrimidine Hydrochloride
2-Cyanopyrimidine
(RS)-3-Aminomethyl-5-Methyl-Hexanoic Acid
3-Isobutyl Glutarimide
(+/-)-3-(Carbamoylmethyl)-5-Methyl Hexanoic Acid
3-Isobutyl Glutaric Acid
(S)-3-Tert-Butylamino-1,2-Propanediol
3-Morpholine-4-Chloro-1,2,5-Thiazole
3,4-Dichloro-1,2,5-Thiadiazole
3,3-Tetramethyleneglutarimide
Calcium Phosphorylcholine Chloride
2-Cyanopyrimidine / CAS 14080-23-0
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DESCRIPTION
2-Cyanopyrimide
CAS No.:14080-23-0
Standard: ≥99%
Package:25KG/ Fibre Drum
Use:Bosentan intermediate
Content:99% MIN
Structure:
Typical Properties
Summary
2-Cyanopyrimidine is a key intermediate in the synthesis of bosentan. Bosentan is a kind of drug for the treatment of pulmonary hypertension, which is suitable for the treatment of patients with pulmonary hypertension (PAH) of who functional classification II-IV (who group 1), in order to improve the exercise ability of patients and reduce clinical deterioration. Studies supporting the effectiveness of this product mainly included patients with idiopathic or hereditary PAH (60%) of who functional classification II-IV, PAH associated with connective tissue disease (21%) and PAH associated with left to right shunt congenital heart disease (18%).
CAS No.
14080-23-0
Formula
C5H3N3
Molecular Mass
105.09700
Exact Mass
105.03300
PSA
49.57000
Logp
0.34828
IUPAC
pyrimidine-2-carbonitrile
SMILES
C1=CN=C(N=C1)C#N
Attribute classification
Matter Classification
organic
Category
API & Intermediate > Pharmaceutical Intermediates
Chemical and Physical Properties
Melting Point
40-44 °C(lit.)
Density
1.22 g/cm3
Boiling Point
250.7ºC
Flash Point
>230 °F
Appearance
White to Yellow Crystalline Powder
Export information
HS Code
29335990
Export Rebate
13%
UN No.
3276
Risk Code
R22-37/38-41-43-34-11-25
Safety Label
Xn,C,F,T
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