2-Picoline / CAS 109-06-8

Basic Information

1. Chinese Name: 2-甲基吡啶
2. English Name: 2-Picoline
3. CAS Number: 109-06-8
4. Molecular Formula: C6H7N
5. Molecular Weight: 93.13
6. Melting Point: -70°C
7. Boiling Point: 128-129°C
8. Relative density: 0.950 (15/4 ℃)
9. Refractive index: 1.5010
10. Flashpoint: 26 ℃
11. Appearance: Colorless liquid
12. Solubility: Miscible with water and most organic solvents

Properties

1. 2-Picoline is an organic compound with a distinctive aromatic odor. It possesses basicity and can neutralize acidic substances.
2. It is miscible with organic solvents such as alcohols and ethers, and is also easily soluble in water.
3. Chemically, 2-Picoline can form salts with inorganic or organic acids and addition compounds with inorganic salts and halogenated alkanes.

Applications

1. Chemical Synthesis: Used as a solvent and chromatography reagent in chemical synthesis, analysis, and pharmaceutical industries.
2. Pharmaceuticals: Employed in the synthesis of biologically active compounds and serves as an intermediate in various drugs, including anti-silicosis medications, livestock dewormers, poultry medications, organophosphorus antidotes, local anesthetics, laxatives, and more.
3. Dyes and Rubbers: Vital raw material for the synthesis of dyes and rubber accelerators.
4. Agriculture: Utilized in the production of fertilizer synergists and herbicides.
5. Other Uses: Serves as an additive in photographic film sensitizers and for the detection of cobalt, cyanates, and iron.

2-pyridine, like pyridine, can form salts with inorganic or organic acids, and add compounds with inorganic salts, halogenated alkanes, etc. During hydrogenation, α - methylpiperidine or pyridine can be obtained under different conditions. The 2-methyl group in 2-methylpyridine is highly reactive, and upon oxidation, it forms pyridine-2-carboxylic acid (Picolinac acid, C5H4NCO2H). In the presence of a dehydrating agent, it condenses with benzaldehyde to form benzyl derivatives. Reacts with polyformaldehyde at 200 ℃ to generate 2- (β - hydroxyethyl) pyridine.