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Xi'an Guokang Ruijin Pharmaceutical Co.,Ltd.
Xi'an Guokang Ruijin Pharmaceutical Co.,Ltd.
6 YRS
Shaanxi, China
Main Products:
Dexamethasone Sodium Phosphate / Dexamethasone / Dexamethasone Acetate / Betamethasone / Progesterone / Sofosbuvir
Shaanxi, China
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Dexamethasone Acetate / CAS 1177-87-3
OVERVIEW
Packaging
1 KG/BOTTLE
Lead Time
14-30 days
Max Capacity
12 MT/Year
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DESCRIPTION
Dexamethasone acetate
Product name: Dexamethasone acetate
Chemical name: (11beta,16alpha)-9-fluoro-11,21-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl acetate
Category: adrenocortical hormone APIs
Specifications: 1kg/tin
Standard: CP/BP/USP/EP
Approval number: Chinese Drug Approval Number H20053752
Quality standard: Chinese Pharmacopoeia 2015 edition
Properties: white or off-white crystal or crystalline powder. No odor, has a little bitter taste.
Identification: positive reaction
Melting point: 223℃~233℃.
Specific rotation: +82º~+88º
Absorbance: 343~371.
Related substances：maximum impurity≤0.5％, total impurities≤1.0%.
Drying loss: ≤0.5%
Residue on ignition: ≤0.1%
Microbial limit: total amount of aerobe≤103cfu/g; mould and yeast≤102cfu/g; no escherichia coli can be detected.
Content: C24H31FO6 content in dry product is 97.0%~102.0%.
Storage: the product should be tightly sealed and kept in shading place.
Chemical structural formula: 
Typical Properties
Summary
Dexamethasone acetate, an adrenocorticotropic hormone, has anti-inflammatory, antiallergic, and antishock effects that are more pronounced than prednisone, whereas it has very mild effects on water and sodium retention and promotion of potassium excretion, and stronger pituitary adrenal suppression. Dexamethasone acetate injection is mainly used in the clinic for allergic versus autoimmune inflammatory diseases. Such as connective tissue diseases, rheumatoid arthritis, severe bronchial asthma, dermatitis and other allergic diseases, ulcerative colitis, acute leukemia, malignant lymphoma and so on.
CAS No.
1177-87-3
Formula
C24H31FO6
Molecular Mass
434.5
Exact Mass
0.0
PSA
100.90000
Logp
2.46650
IUPAC
[2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
SMILES
CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)COC(=O)C)O)C)O)F)C
Attribute classification
Matter Classification
organic
Category
API & Intermediate > Hormones And Endocrine Drugs
Chemical and Physical Properties
Melting Point
238-240 °C(lit.)
Density
1.1517 (estimate)
Boiling Point
579.4±50.0 °C(Predicted)
Flash Point
304.2ºC
Appearance
White or whitish crystalline or crystalline powder
Export information
HS Code
29372210
Export Rebate
13%
Export Formalities
Q
UN No.
0.0
DG-Class
0.0
Risk Code
43
Safety Label
Xi
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