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Xi'an Guokang Ruijin Pharmaceutical Co.,Ltd.
Xi'an Guokang Ruijin Pharmaceutical Co.,Ltd.
6 YRS
Shaanxi, China
Main Products:
Dexamethasone Sodium Phosphate / Dexamethasone / Dexamethasone Acetate / Betamethasone / Progesterone / Sofosbuvir
Shaanxi, China
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Betamethasone / CAS 378-44-9
OVERVIEW
Packaging
1 KG/BOTTLE
Lead Time
14-30 days
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DESCRIPTION
Betamethasone
Product name: Betamethasone
Chemical name: 9a-fluoro-11b,17a,21-trihydroxy-16b-methylpregna-1,4-diene-3,20-dione
Category: adrenocortical hormone APIs
Specifications: 1kg/tin
Standard: CP/BP/USP/EP
Approval number: Chinese Drug Approval Number H20055125
Quality standard: Chinese Pharmacopoeia 2015 edition
Properties: white or off-white crystalline powder; no odor.
Identification: positive reaction
Melting point: 236℃~244℃.
Specific rotation: +115º~+121º
Absorbance:382~406
Related substances：maximum impurity≤1.0％, other single impurities≤0.5％, total impurities≤2.0％.
Drying loss: ≤0.5%.
Residue on ignition: ≤0.1%.
Microbial limit: total amount of aerobe≤103cfu/g; mould and yeast≤102cfu/g; no escherichia coli can be detected.
Content: C22H29FO5 in dry product is 97.0%~103.0%.
Storage: the product should be tightly sealed and kept in shading place.
Chemical structural formula: 
Typical Properties
Summary
Hormone drugs. It is mainly used for anti-inflammatory and anti allergy. It is suitable for rheumatoid arthritis and various skin diseases. Betamethasone has the same effect as dexamethasone, and its anti-inflammatory effect is stronger than dexamethasone, desmoxone and hydrocortisone, and its side effects are less.
CAS No.
378-44-9
Formula
C22H29FO5
Molecular Mass
392.46100
Exact Mass
392.20000
PSA
94.83000
Logp
1.89570
IUPAC
(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
SMILES
CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C
Attribute classification
Matter Classification
organic
Category
API & Intermediate > Hormones And Endocrine Drugs
Chemical and Physical Properties
Melting Point
235-237°C
Density
1.32g/cm3
Boiling Point
568.2ºC
Flash Point
297.5ºC
Appearance
White to grayish white crystalline powder
Acidity and Basicity
reducibility neutral
Export information
HS Code
29372290
Export Rebate
13%
Export Formalities
Q
Risk Code
R40-48/20/21-61
Safety Label
Xi,Xn,T
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