2-[4-(1,3-Benzodioxol-5-Ylmethyl)Piperazin-1-Yl]Pyrimidine / CAS 3605-01-4

Piribedil is a kind of peripheral and cerebral vasodilator commonly used in clinic. It is a dopamine receptor agonist. It can be used alone or in combination with levodopa in the treatment of Parkinson's disease. It can improve some symptoms caused by intelligence deficiency in the elderly, such as decreased attention and memory, vertigo, intermittent claudication (stage 2) caused by arterial embolism of lower limbs. Retinal defect attack, improve visual acuity, similar to dopamine, side effects similar to levodopa. In addition, this product can also improve the peripheral blood circulation, and has certain curative effect on obstructive or embolic fundus diseases. Piribedil can stimulate the postsynaptic D2 receptors in substantia nigra and striatum, and D2 and D3 receptors in midbrain cortex and midbrain limbic lobe pathway to provide effective dopamine effect. During the treatment, piribedil stimulates cortical electrogenesis in the form of "dopaminergic", which has clinical effect on various functions induced by dopamine. For the peripheral circulation, the drug can increase the blood flow of femoral vessels, which may be due to the inhibition of sympathetic tension.