Tolvaptan

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Tolvaptan

CAS NO.： 150683-30-0

FOB Price： NEGOTIABLE Get Latest Price

Specification： 99.5％

Documentation： Get COA after inquiry

Lead Time： 14-30 days

Max Capacity： -

Packing： 25KG/Fibre Drum

Product Detail

Properties

Tovaptan

English Name: tolvaptan

CAS No.: 150683-30-0

Molecular formula: C26H25ClN2O3

Molecular weight: 448.94

EINECS No.: 691-537-5

Melting point: 219-222 ° C

Boiling point: 594.4 ± 50.0 ° C (predicted)

Density: 1.311 ± 0.06 g / cm3 (predicted)

Purpose: tovaptan is an oral selective vasopressin antagonist developed by Otsuka company for the treatment of hyponatremia. It belongs to non peptide selective antidiuretic hormone V2 receptor antagonist. It can increase the concentration of sodium ion in plasma, help excess water to be discharged from urine, have strong diuretic effect, enhance the ability of kidney to treat water, and significantly reduce patient weight and edema, It can be used to treat hyponatremia caused by congestive heart failure, various edema diseases, liver cirrhosis and syndrome of insufficient secretion of antidiuretic hormone.

Properties

Tovaptan was developed by Otsuka company of Japan and approved by FDA in 2009 for the treatment of patients with heart failure. The trade name of tovaptan tablets is sumeka. The difficulty of its synthesis route is mainly reflected in the construction of benzo seven membered ring. The treatment of heart failure is a research hotspot, and the development of new diuretics is one of its strategic objectives. Therefore, antagonizing arginine vasopressin is an effective method to prevent the development of heart failure.

CAS No.

150683-30-0

Formula

C26H25ClN2O3

Molecular Mass

448.94100

Exact Mass

448.15500

PSA

69.64000

Logp

5.82110