Nitrofurazone

Product name：Nitrofurazone

Alias：Furacilin，Mammex，Nifuzon，Nitrofural，Vabrocid

Molecular formula： C6H6N4O4

Molecular Weight：198.14

Properties：It is a lemon yellow fine crystalline powder; odorless, bitter.

Physical Properties: Yellow crystalline powder. Melting point 236-240 ° C (decomposition). 1 part of the product is soluble in 4200 parts of water; 590 parts of ethanol, almost insoluble in ether; chloroform. The pH of the saturated solution is 6.0-6.5. Odorless, bitter. The color is darker in daylight.

Uses: Clinically only used as a disinfectant antiseptic for skin and mucous membrane infections, such as suppurative otitis media, suppurative dermatitis, acute and chronic rhinitis, burns, ulcers, etc. There is no stimulation to the tissue; pus or blood has no significant effect on its disinfection.

Properties

Nitrofurazone appears as odorless pale yellow needles or yellow powder. pH (saturated aqueous solution) 6.0 - 6.5. Alkaline solutions are dark orange. (NTP, 1992) Nitrofurazone is a semicarbazone resulting from the formal condensation of semicarbazide with 5-nitrofuraldehyde. A broad spectrum antibacterial drug, although with little activity against Pseudomonas species, it is used as a local application for burns, ulcers, wounds and skin infections. It has a role as an antibacterial drug. It is a semicarbazone and a nitrofuran antibiotic. A topical anti-infective agent effective against gram-negative and gram-positive bacteria. It is used for superficial WOUNDS AND INJURIES and skin infections. Nitrofurazone has also been administered orally in the treatment of TRYPANOSOMIASIS.

CAS No.

59-87-0

Formula

C6H6N4O4

Molecular Mass

198.136

Exact Mass

198.039

PSA

126.44000

Logp

1.80440