Synopsis：Zidovudine is a synthetic thymidine antiviral drug and became the first drug approved for the treatment of Acquired Immune Deficiency Syndrome (AIDS). Zidovudine is a water-soluble molecule that requires a specific transfer protein to enter the cell, and then is phosphorylated into a triphosphate active derivative by the corresponding kinase, and then inhibits the activity of the viral reverse transcriptase, and terminates the elongation of the viral DNA chain. Inhibiting the replication of the virus to achieve antiviral effects can improve the clinical symptoms of HIV-infected patients and reduce their mortality.
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Summary
Zidovudine is a synthetic thymidine antiviral drug and became the first drug approved for the treatment of Acquired Immune Deficiency Syndrome (AIDS). Zidovudine is a water-soluble molecule that requires a specific transfer protein to enter the cell, and then is phosphorylated into a triphosphate active derivative by the corresponding kinase, and then inhibits the activity of the viral reverse transcriptase, and terminates the elongation of the viral DNA chain. Inhibiting the replication of the virus to achieve antiviral effects can improve the clinical symptoms of HIV-infected patients and reduce their mortality.
CDMO
