The liquid-phase catalytic hydrogenation reduction process is adopted, and the 8-hydroxyquinoline (CAS 148-24-3) product has a high yield, good grade, and environmental protection.

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400 Metric Tons per Year

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Specifications of 8-Hydroxyquinoline(CAS 148-24-3)

Brief Introduction of 8-Hydroxyquinoline(8HQ, CAS 148-24-3)

8-Hydroxyquinoline is an organic compound. White or light yellow crystal or crystalline powder. 8-Hydroxyquinoline is insoluble in water and ether, soluble in ethanol, acetone, chloroform, benzene or dilute acid, and capable of sublimation.

On October 27, 2017, the list of carcinogens published by the international agency for research on cancer of the World Health Organization was preliminarily sorted for reference, and 8-hydroxyquinoline was included in the list of class 3 carcinogens.

Applications of 8-Hydroxyquinoline(CAS 148-24-3)

(1) As a pharmaceutical intermediate, 8-hydroxyquinoline is the raw material for the synthesis of Oxyquinoline phthalyl sulfathiazole, chloroiodoquinoline and paracetamol. 8-hydroxyquinoline is also an intermediate of halogenated quinoline anti amoeba drugs, including quiniodoform, chloroiodoquinoline, diioquinoline and so on. These drugs play an anti amebic role by inhibiting intestinal symbiotic bacteria. They are effective for amebic dysentery and have no effect on extraintestinal amoeba protozoa. In recent years, it has been reported that this kind of drug can cause subacute spinal cord optic neuropathy, so it has been banned in Japan and the United States.

(2) 8-hydroxyquinoline can be dyestuff Intermediates and agrochemical Intermediates.

(3) The sulfate and copper salt of 8-hydroxyquinoline are excellent preservatives, disinfectants and fungicides, such as Quinoline copper.

(4) 8-hydroxyquinoline is used as a reagent for the determination of bismuth, magnesium, copper, zinc and organic element nitrogen, as a complexing agent and extractant for precipitation and separation of metal ions.

(5) 8-hydroxyquinoline can be used as an inhibitor of RNA synthesis and has bactericidal and inhibitory effects on Trichophyton agrophytes, Myrothecium Verrucaria and Trichoderma viride

(6) Adding 8-hydroxyquinoline into epoxy resin adhesive can improve the bonding strength and heat aging resistance to metals (especially stainless steel), and the dosage is generally 0.5 ~ 3 phr. 8-hydroxyquinoline can be used as a stabilizer for polyester resin, phenolic resin and hydrogen peroxide.

(7) 8-hydroxyquinolines also act as veterinary drug intermediates, mainly in the synthesis of haquinol. Haquinol is a veterinary drug substance mainly used for intestinal infectious diseases and prevention of forage mold infection. Haquinol can interfere with the synthesis of the mold cell wall and inhibit mold growth and reproduction by chelating with metal ions such as iron, copper and zinc, so that the bacteria cannot utilize the necessary metal ions, thereby inhibiting the growth and reproduction of the mold. In addition, haquinol acts directly on the gastrointestinal smooth muscle of animals and is particularly effective in dysentery-afflicted livestock by reducing gastrointestinal motility and increasing nutrient absorption.

Synthesized Method of 8-Hydroxyquinoline(CAS 148-24-3)

At present, there are two Synthesized Methods of 8-hydroxyquinoline, the quinoline method and the glycerol method, quinoline method is used in cosmetics, and we are the glycerol method, the process leading, produced from o-aminophenol via cycle reaction. Glycerol was added to an acid-fast reaction pot, and concentrated sulfuric acid was added slowly with stirring, while O-aminophenol and O-nitrophenol were added sequentially, and fuming sulfuric acid was added to 65% of the total. The heating was raised to 125 ° C, stopped heating, and raised naturally to 140 ° C, pending the temperature return to 136 ° C. The rest of the fuming sulfuric acid was continued and the temperature was maintained at 137 ° C. At the end of acid addition, the dish was incubated for 4 h, cooled to below 100 ° C, pumped into an acid-fast pot containing 10 times the amount of water (by o-aminophenol), stirred, heated to 75-80 ° C, and neutralized with 30% sodium hydroxide solution to a pH of 7-7.2. The precipitate was evolved while hot, cooled to bulk, and sublimed under reduced pressure to yield the 8-hydroxyquinoline finished product.

Qinyang Hongsheng Fine Chemical Co., Ltd. was established in April 2011 with a registered capital of 10 million yuan. The company is located in Qinbeiyuan District, Qinyang industrial agglomeration area (West to the north of town). The main products include o-nitrophenol, o-aminophenol, 4-chloro-o-aminophenol, p-chloro-o-nitrophenol, 8-hydroxyquinoline, 8-hydroxyquinoline aluminum, 8-hydroxyquinoline copper, 8-hydroxyquinoline salt, 5-chloro-hydroxyquinoline, o-amino-p-tert-butyl phenol, 4,4 '- diaminodiphenyl ether and other hydrogenation series products with an annual output of 10000 tons.

Factory and laboratories of Hongsheng Fine Chemical

The most advanced liquid-phase catalytic hydrogenation reduction process in the world is adopted in the production process of the project. It is characterized by high product yield, good grade and no three wastes. It is a green environmental protection process. With sophisticated equipment, advanced technology, strong technical force and complete testing means, the company is a scientific and technological enterprise integrating scientific research, production and marketing.

Keywords

8-Hydroxyquinoline; CAS 148-24-3; 8-Oxyquinoline; Quinolin-8-ol; Hydroxyquinoline CAS 148-24-3; 8-Hydroxyquinoline manufacturers; 8-Hydroxyquinoline CAS 148-24-3 suppliers; China 8-Hydroxyquinoline; 99% 8-Hydroxyquinoline; 8-Hydroxyquinoline 8-HQ.

FAQ of Hongsheng Fine Chemical

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① Our factory is famous for its comparison in foreign markets, with a continuous and stable supply of products. Most other domestic counterparts are intermittent, few factories can be stably supplied.

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