Cladribine

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Cladribine

CAS NO.： 4291-63-8

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Specification： USP, EP

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Lead Time： 14-30 days

Max Capacity： -

Packing： 25KG/Fibre Drum

Product Detail

Properties

Cladribine

CAS No.: 4291-63-8

Molecular formula: C10H12ClN5O3

Molecular weight: 285.68

Melting point: 181-185 ℃

Appearance: white solid

Application: antitumor drugs

Properties

Cladribine is a purine analogue and antineoplastic agent used primarily in the therapy of hairy cell leukemia. Cladribine is typically given intravenously daily for 7 days, usually as a single course, and has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent acute liver injury with jaundice. Cladribine is 2'-Deoxyadenosine in which the hydrogen at position 2 on the purine ring has been substituted by chlorine. It inhibits the synthesis and repair of DNA, particularly in lymphocytes and monocytes, and is used as an antimetabolite antineoplastic drug for the treatment of lymphoid malignancies including hairy-cell leukaemia and chronic lymphocytic leukaemia. It has a role as an antineoplastic agent and an immunosuppressive agent. It is a purine 2'-deoxyribonucleoside and an organochlorine compound.

CAS No.

4291-63-8

Formula

C10H12ClN5O3

Molecular Mass

285.68700

Exact Mass

285.06300

PSA

119.31000

Logp

0.28380

IUPAC

(2R,3S,5R)-5-(6-amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol

Matter Classification

organic

Category

Melting Point

181-185 °C

Density

2.03g/cm3

Boiling Point

547.6ºC

Flash Point

285ºC

Appearance

White solid

Acidity and Basicity

alkalinity

HS Code

29349990

Export Formalities

UN No.

2811

DG-Class

6.1

Risk Code

R36/37/38-23/24/25

Safety Label

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