Purpose:Bortezomib is the first proteasome inhibitor approved by FDA for multiple myeloma (a blood cancer). Reversible 26S proteasome inhibitor, a barrel shaped multi protein particle, exists in the nucleus and cytoplasm of all eukaryotic cells.
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Summary
Bortezomib is the first proteasome inhibitor approved by FDA for multiple myeloma (a blood cancer). Reversible 26S proteasome inhibitor, a barrel shaped multi protein particle, exists in the nucleus and cytoplasm of all eukaryotic cells. Targeting ubiquitin proteasome pathway.