Cytarabine

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Cytarabine

CAS NO.： 147-94-4

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Product Detail

Properties

Cytarabine

CAS No.: 147-94-4

Molecular formula: C9H13N3O5

Molecular weight: 243.21

Melting point: 214 ℃

Appearance: white fine acicular crystal or crystalline powder

Application: antitumor drugs

Properties

Cytarabine is a kind of purine nucleoside antiviral drug which is extracted from Streptomyces culture medium and synthesized by chemical method. It is slightly soluble in water, and its monophosphate is easily soluble in water. It can inhibit HSV1 and HSV2, hepatitis B virus, varicella zoster virus and cytomegalovirus, but has no effect on smallpox virus, adenovirus, other DNA or RNA viruses, bacteria and fungi. At present, the exact mechanism of cytosine arabinoside antiviral has not been fully elucidated, which is mainly related to the inhibition of virus replication. Drugs and their metabolites block the synthesis of viral DNA by inhibiting viral DNA polymerase, while drugs only penetrate into viral DNA molecules in a very small amount. Cytarabine is also one of the most effective drugs for the treatment of acute non lymphocytic myeloid leukemia in China.

CAS No.

147-94-4

Formula

C9H13N3O5

Molecular Mass

243.21700

Exact Mass

243.08600

PSA

130.83000

Logp

-1.98180

IUPAC

4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

Matter Classification

organic

Category

Melting Point

214 °C

Density

1.89 g/cm3

Boiling Point

545.7 ºC

Flash Point

283.8 ºC

Appearance

White fine acicular crystal or crystalline powder

Acidity and Basicity

acidness

HS Code

29349990

Risk Code

R43-63-36/37/38-20/21/22

Safety Label

Xn,Xi

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