Palbociclib

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Palbociclib

CAS NO.： 571190-30-2

FOB Price： NEGOTIABLE Get Latest Price

Specification： ≥99%

Documentation： Get COA after inquiry

Lead Time： 14-30 days

Max Capacity： -

Packing： 25KG/Fibre Drum

Product Detail

Properties

Palbociclib

Product Name:Palbociclib

Chinese Name:帕博西尼

CAS NO.：571190-30-2

Molecular formula: C24H29N7O2

Molecular weight: 447.54

Specification content: ≥ 99%

Properties

Pabcicilib is an inhibitor of cyclin dependent kinase (CDK) 4 and 6. Cyclin D1 and CDK4 / 6 are downstream signaling pathways leading to cell proliferation. In vitro, the proliferation of ER positive breast cancer cells was inhibited by blocking the progression from G1 to S phase. Compared with the treatment of each drug alone, the combination of pabacib and anti estrogen resulted in decreased phosphorylation of retinoblastoma protein (RB), decreased E2F expression and signal, and prevented growth. In vitro treatment of ER positive breast cancer cell lines with combination of pabacib and anti estrogen resulted in increased cell senescence, which lasted up to 6 days after drug removal.

CAS No.

571190-30-2

Formula

C24H29N7O2

Molecular Mass

447.53

Exact Mass

447.23800

PSA

105.04000

Logp

3.43260

IUPAC

6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7-one

Matter Classification

organic

Category

Melting Point

200 ºC

Density

1.313 g/cm3

Boiling Point

711.5 °C

Flash Point

384.1ºC

Appearance

white to beige powder

Acidity and Basicity

alkalinity

HS Code

29335990

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Chongqing Beisheng Pharmaceutical Co.,Ltd.

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