Fulvestrant

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Fulvestrant

CAS NO.： 129453-61-8

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Packing： 25KG/Fibre Drum

Product Detail

Properties

Fulvestrant

[Product Name]: Fulvestrant

[Chemical Name]: (7a,17b)-7-[9-[(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-diol

[Structure]:

[Molecule]: C32H47F5O3S

[Molecular Weight]: 606.77

[CAS NO.]:129453-61-8

Properties

Fluticasone is an intramuscular injection developed by AstraZeneca. It was approved by the food and Drug Administration in April 2002 to treat estrogen receptor positive metastatic breast cancer in postmenopausal women whose disease is still deteriorating after anti estrogen therapy. Many breast cancer cells have estrogen receptor (ER), estrogen can stimulate the growth of such tumors. Fluvestrant is a "pure" estrogen receptor antagonist without partial estrogen like agonistic effect. It inhibits estrogen signal pathway by binding, blocking and down regulating er. It can competitively bind with ER. Its affinity with Er is close to estrogen, 100 times that of tamoxifen. It is the only anti estrogen drug that can be widely used in clinic after tamoxifen fails, Because the drug is endocrine therapy and will not cause common adverse reactions of chemotherapy, it has good patient compliance.

CAS No.

129453-61-8

Formula

C32H47F5O3S

Molecular Mass

606.77100

Exact Mass

606.31700

PSA

76.74000

Logp

9.54830

IUPAC

(7R,8R,9S,13S,14S,17S)-13-methyl-7-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl]-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol

Matter Classification

organic

Category

Melting Point

104-106°C

Density

1.201 g/cm3

Boiling Point

674.8ºC at 760 mmHg

Flash Point

361.9ºC

Appearance