Overview: clofarabine is a nucleotide analogue, which combines the advantages of fludarabine and cladribine. It inhibits both DNA polymerase and RNA reductase. It is the only drug suitable for the treatment of childhood leukemia.
Properties
Summary
Second generation purine nucleoside analog; antimetabolite that inhibits DNA synthesis and resists deamination by adenosine deaminase. Antineoplastic.
CRO
