Granisetron Hydrochloride

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CAS NO.： 107007-99-8

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Specification： 99%

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Lead Time： 14-30 days

Max Capacity： -

Packing： 25KG/Fibre Drum

Product Detail

Properties

Granisetron Hydrochloride

[Chinese name]: 盐酸格拉司琼

[IUPAC name]：1-Methyl-N-(9-Methyl-9-Azabicyclo(3.3.1)Non-3-Yl)-1H-Indazole-3-Carboxamid

[Structural type]:

[Molecular formula]: C18H25ClN4O

[Molecular weight]: 312.4094

[CAS NO.] 107007-99-8

Properties

Granisetron hydrochloride is a highly selective 5-HT3 receptor antagonist, which has good preventive and therapeutic effects on nausea and vomiting caused by radiotherapy, chemotherapy and surgery. Radiotherapy, chemotherapy and surgery can cause the release of 5-HT from the intestinal chromaffin cells. 5-HT can activate the 5-HT3 receptor of the central or vagus nerve and cause vomiting reflex. The mechanism of controlling nausea and vomiting is to inhibit the occurrence of nausea and vomiting by antagonizing 5-HT3 receptors in central chemosensory area and peripheral vagus nerve endings. It has high selectivity and no side effects such as extrapyramidal reaction and excessive sedation.

CAS No.

107007-99-8

Formula

C18H25ClN4O

Molecular Mass

348.87000

Exact Mass

348.17200

PSA

50.16000

Logp

3.44920