Valsartan

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Valsartan

CAS NO.： 137862-53-4

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Specification： CP/USP/EP

Documentation：

COA

Lead Time： 14-30 days

Max Capacity： -

Packing： 20KG/Fibre Drum; 1KG/Paper Bag

Product Detail

Properties

Product name:Valsartan

CAS No.:137862-53-4

Formula:C₂₄H₂₉N₅O₃=435.53

Specification:USP/Medicinal Standards of State Food and Drug Administration of china

Physical and Chemical Characteristics:

White or almost white crystalline powder,odorless.

Soluble in ethanol and methanol and slightly soluble in water.

Melting range:197—200

Usage:medicine for circulatory system. Anti hypertension, mild to moderate essential hypertension.

Package and storage:Net 20kg per fiber drum or net 1kg per aluminous bag,which is lined with PE bag and Kraft bag. Lead sealed iron round fastens the drum head with drum body.

Keep container tightly closed from moisture and light.

Properties

Valsartan is a specific angiotensin Ⅱ (AT1) receptor antagonist. It is also a non skin AT1 receptor antagonist after losartan. It plays a key role in regulating systemic blood pressure and maintaining electrolyte and body fluid balance. It selectively acts on AT1 receptor subtypes and blocks the binding of Ang Ⅱ to AT1 receptor (its specific antagonistic effect against AT1 receptor is about 20000 times greater than that of AT2 receptor), thus inhibiting vasoconstriction and aldosterone release, resulting in hypotensive effect, but not inhibiting aldosterone release induced by potassium ion (K +). The antihypertensive effect is superior to enalapril in the treatment of hypertension, mild to moderate essential hypertension, especially for secondary hypertension caused by kidney damage. It can significantly reduce proteinuria in hypertensive patients with normal diabetes or normal renal function, and has the protective effect of promoting uric acid and urinary sodium excretion. It is also suitable for reducing the cardiovascular mortality of high-risk patients (left ventricular failure or left ventricular dysfunction) after heart attack.

CAS No.

137862-53-4

Formula

C24H29N5O3

Molecular Mass

435.51900

Exact Mass

435.22700

PSA

112.07000

Logp

4.16170

IUPAC

(2S)-3-methyl-2-[pentanoyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]amino]butanoic acid

Matter Classification

organic

Category

Melting Point

116-117 °C

Density

1.212 g/cm3

Boiling Point

684.9 ºC

Flash Point

368 ºC

Appearance

White crystalline powder

Acidity and Basicity

acidness

HS Code

29339900

Risk Code

R36/37/38

Safety Label

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