English Name:

Orlistat

CAS No.:

96829-58-2

Molecular formula:

C29H53NO5

Molecular weight:

495.73

Melting point

<50°C

Storage conditions

2-8°C

Solubility

DMSO: 19mg/mL

Appearance

solid

Colour

White to off-white crystalline powder

New slimming and lipid-lowering drugs

Orlistat is a long-acting and powerful specific gastrointestinal lipase inhibitor. It is white or almost white powder at room temperature, insoluble in water, soluble in chloroform and easily soluble in ethanol. It inactivates the enzyme by forming covalent bonds with the active serine sites of gastric lipase and pancreatic lipase in the stomach and small intestine.

Pharmacological action

Orlistat is a kind of lipase inhibitor weight loss drug. It is a hydrated derivative of lipostatin, which can reduce the absorption of food fat and reduce weight. This product has strong and selective inhibition of gastric lipase and pancreatic lipase, has no effect on other digestive enzymes (amylase, trypsin, chymotrypsin) and phospholipase, and does not affect the absorption of carbohydrates, proteins and phospholipids. The drug is not absorbed by the gastrointestinal tract, and the inhibitory effect on lipase is reversible.