API & Intermediate

Capecitabine, an antimetabolite fluoropyrimidine deoxynucleoside carbamate that can be converted to 5-FU in vivo, was developed by Roche under the trade name hiloda and is able to inhibit cell division and interfere with RNA and protein synthesis. For further treatment of paclitaxel and advanced primary or metastatic breast cancer including patients refractory to chemotherapeutic regimens with anthracyclines. It is mainly used for the treatment of advanced primary or metastatic breast, rectal, colon and gastric cancer.

In addition to being used as an anthelmintic, levamisole hydrochloride also has immunomodulatory effect, which can effectively improve the immune function of patients. Levamisole can regulate the immune function, mainly on T lymphocytes, to induce the early differentiation and maturation of T cells into functional T cells, so as to promote the normal function of T cells. It can also strengthen the phagocytosis and chemotaxis of macrophages, so as to improve the activity of natural killer cells, produce endogenous interferon, improve the immune function and make it normal, and effectively prevent the progress of pneumonia, Improve cough, lung sounds and other symptoms. In addition, after the immune function of children is weakened, levamisole hydrochloride can increase the content of total complement in blood, especially the production of IgG and IgA, so as to improve the immune effect of respiratory tract Ru membrane, and play the role of virus resistance and anti bacterial infection. Levamisole can not only regulate the immune function, but also restore the immune function. It can show two-way regulation for the abnormal humoral immune function, make it tend to normal development, and help the low cellular immune function return to normal.

3-Fluorobenzoyl chloride can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly in laboratory R & D process and chemical production process. Also used as dyes, pesticides, pharmaceutical intermediates.

Posaconazole is used in patients with invasive aspergillosis refractory to amphotericin B or itraconazole or in patients who cannot tolerate treatment with these agents.It is clinically useful in the treatment of aspergillosis, zygomycosis and sickle cell disease, but also in the treatment of some fluconazole resistant Candida infections.

Endo Cave hydrate is a new type of cyclopentylguanosine anti HBV drug. Its pharmacological action is similar to that of entredo Cave. It is clinically suitable for the treatment of chronic hepatitis B with active viral replication, elevated serum aminotransferase ALT or liver histology showing active lesions. This product is guanine nucleoside analogue and has inhibitory effect on hepatitis B virus (HBV) polymerase.