Folinic Acid Calcium Salt; Levoleucovorin Calcium; Fusilev (Tn); Levoleucovorin (Calcium); UNII-778XL6VBS8; Isovorin (Tn); 778Xl6Vbs8; Calcium Levofolinate (Inn); Levofolinate Calcium (Jan); Calcium,(2S)-2-[[4-[[(6S)-2-Amino-5-Formyl-4-oxo-1,6,7,8-Tetrahydropteridin-6-yl]Methylamino]Benzoyl]Amino]Pentanedioate; L-Leucovorin Calcium; Calcium (6s)-Folinate

Brief Introduction

Levoleucovorin Calcium is a levo isoform of leucovorin calcium with antineoplastic activity. Levoleucovorin is an active metabolite of folic acid, which does not require metabolism by dihydrofolate reductase. This agent counteracts the toxic effects of other folic acid derivative agents, rescuing the patient while permitting the antitumor activity of the folate antagonist. This agent also potentiates the effects of fluorouracil and its derivatives by stabilizing the binding of the drug's metabolite to its target enzyme, thus prolonging drug activity.

Tamoxifen

CAS:10540-29-1

Molecular Formula:C26H29NO

Alias

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Tamoxifene; [3H]-Tamoxifen; [14C]-Tamoxifen; Tamoxen; Valodex; Oncomox; Citofen; Diemon; Soltamox; Crisafeno; Tamizam; Mammaton; Trans-2-[4-(1,2-Diphenyl-1-Butenyl)Phenoxy]-N,N-Dimethylethylamine; (Z)-1-{4-[2-(Dimethylamino)Ethoxy]-Phenyl}-1,2-Diphenyl-1-Butene; 2-[4-[(Z)-1,2-Di(Phenyl)But-1-Enyl]Phenoxy]-N,N-Dimethylethanamine; 2-[4-[(Z)-1,2-Diphenyl-1-Butenyl]Phenoxy]-N,N-Dimethylethanamine; 2-[P-[(Z)-1,2-Diphenyl-1-Butenyl]Phenyloxy]-N,N-Dimethylethanamine; N,N-Dimethyl-2-[P-[(Z)-1,2-Diphenyl-1-Butenyl]Phenoxy]Ethanamine; (Z)-1-(P-Dimethylaminoethoxyphenyl)-1,2-Diphenyl-1-Butene, Trans-2-[4-(1,2-Diphenyl-1-Butenyl)Phenoxy]-N,N-Dimethylethylamine

Brief Introduction

Tamoxifen is a non sterol anti estrogen drug. Its structure is similar to that of estrogen, and there are two isomers, Z-type and E-type. Both have different physical and chemical properties and physiological activities. Type E has weak estrogen activity and type Z has anti estrogen effect. If there is estrogen receptor (ER) in breast cancer cells, estrogen enters the tumor cells and combines with it to promote the synthesis of DNA and mRNA of tumor cells and stimulate the growth of tumor cells. The z-isomer of tamoxifen enters the cell and competes with the ER to form a receptor complex, which prevents the role of estrogen and inhibits the proliferation of breast cancer cells.

Exemestane

CAS:107868-30-4

Molecular Formula:C20H24O2

Alias

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Aromasin; Exemestan; 6-Methylene-Androsta-1,4-Diene-3,17-Dione; 6-Methyleneandrosta-1,4-Diene-3,17-Dione; Exalamide; 6-Methylenandrost-1,4-Diene-3,17-Dione; Androsta-1,4-Diene-6-Methylene-3,17-Dione; 6-Methylenandrosta-1,4-Diene-3,17-Dione; Exemestance

Brief Introduction

Exemestane is an irreversible steroid aromatase inhibitor with a structure similar to its natural androstenedione substrate. The use of aromatase to remove estrogen is an effective and alternative treatment for hormone dependent breast cancer in postmenopausal women. It is used for advanced breast cancer in natural or postmenopausal women whose condition is still not progresses after tamoxifen treatment.

Abiraterone Acetate

CAS:154229-18-2

Molecular Formula:C26H33NO2

Alias

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17-(3-Pyridyl)-5,16-Androstadien-3Beta-Acetate; 2-((3S,8R,9S,10R,13S,14S)-10,13-Dimethyl-17-(Pyridin-3-Yl)-2,3,4,7,8,9,10,11,12,13,14,15-Dodecahydro-1H-Cyclopenta[A]Phenanthren-3-Yl)Acetate; Abiraterone

Brief Introduction

Abiraterone acetate is a sterol ester obtained by formal condensation of the 3-hydroxy group of abiraterone with the carboxy group of acetic acid. A prodrug that is converted in vivo into abiraterone. Used for treatment of metastatic castrate-resistant prostate cancer. It has a role as a prodrug, an antineoplastic agent and an EC 1.14.99.9 (steroid 17alpha-monooxygenase) inhibitor. It is a sterol ester and a member of pyridines. It derives from an abiraterone.

Cisplatin

CAS:15663-27-1

Molecular Formula:Cl2H6N2Pt

Alias

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Cis-Diammineplatinum Dichloride; Cis-Diamineplatinum(Ii) Dichloride; Cis-Platinum(Ii) Diammine Dichloride; Cis-Diammineplatinum(Ii) Dichloride (Cis-Dichlorodiammine Platinum(Ii); Cis-Diammineplatinum(Ii) Dichloride; Cis-Dichlorodiammine Platinum(Ii); Cis-Diamminedichloroplatinum(Ii); Cis-Dichlorodiamineplatinum(Ii); Lederplatin; Briplatin; Diamminedichloroplatinate (Ii); Cpdc; Cismaplat; Cisplatiin; Cisplatin Dihydrochloride

Brief Introduction

This product can combine with DNA and cause cross connection, thus damaging the function of DNA and inhibiting cell mitosis. It is a cell non-specific drug. The product has a wide anti-tumor spectrum, and is used for head and neck squamous cell carcinoma, ovarian cancer, embryogenic carcinoma, seminoma, lung cancer, thyroid cancer, lymphosarcoma and reticulosarcoma.

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