Pharmaceutical Intermediates

3,5-Bis(2-Cyanoprop-2-yl)Toluene can be used as an intermediate of anastrozole.

4-Hydroxybenzaldehyde is an important intermediate of medicine, perfume and liquid crystal. Anisaldehyde can be prepared by reaction with dimethyl sulfate, 4-hydroxycinnamaldehyde can be prepared by reaction with acetaldehyde, and cinnamic acid can be prepared by further oxidation. This product can be used as perfume, pharmaceutical intermediate, liquid crystal raw material and other organic synthesis intermediate. The main use of 4-hydroxybenzaldehyde is in the perfume industry for the synthesis of vanillin, ethyl vanillin, eugenol, anisaldehyde and fupenone.

Tert-butyl 2-[(4R,6R)-6-(cyanomethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetate is used as an intermediate of atorvastatin. Atorvastatin is a selective competitive HMG CoA reductase inhibitor, which can significantly reduce LDL CH and triglyceride, but does not cause the redistribution of triglyceride, but constantly reduces TG in all lipoprotein components. It is suitable for the patients with primary hypercholesterolemia, heterozygous familial hypercholesterolemia or mixed hyperlipidemia, whose diet control can not effectively reduce the average total cholesterol, low density lipoprotein cholesterol and triglyceride. It is also suitable for patients with heterozygous familial hypercholesterolemia who have diet control at the same time.

Pyruvate is a component of human body, which is mainly involved in the metabolism of sugar and fat in human body, and is also one of the intermediate products of carbohydrate metabolism. Pyruvic acid and its salt are widely used in medicine field, and are used to produce tranquilizers, antioxidants, disease resistant agents, synthetic drugs for hypertension and so on. Pyruvic acid can be used in the synthesis of medicine and amino acids, which can improve the production efficiency, especially in pharmaceutical industry, it can shorten the process and simplify the process. For example, 2-phenyloctenic acid, which is made of this product, is a kind of antipyretic and analgesic and diuretic drug. Using this product as raw material can greatly reduce the production cost. It is also used as the anti tuberculosis drug, calcium isoniazide pyruvate, hormone synthesis, pyreniumapamote as an insecticide, and also as pesticide raw materials. The tryptophan can be produced by biochemical reaction from pyruvic acid, indole and ammonia, and it can also be used to produce MSG and spices.

Tetraacetylribose is an important intermediate for the production of antiviral Triazole Nucleoside in the pharmaceutical industry. It is mainly used to synthesize broad-spectrum antiviral drug ribavirin. It is also the starting material for the synthesis of nucleoside compounds.