Pharmaceutical Intermediates

Pyruvate is a component of human body, which is mainly involved in the metabolism of sugar and fat in human body, and is also one of the intermediate products of carbohydrate metabolism. Pyruvic acid and its salt are widely used in medicine field, and are used to produce tranquilizers, antioxidants, disease resistant agents, synthetic drugs for hypertension and so on. Pyruvic acid can be used in the synthesis of medicine and amino acids, which can improve the production efficiency, especially in pharmaceutical industry, it can shorten the process and simplify the process. For example, 2-phenyloctenic acid, which is made of this product, is a kind of antipyretic and analgesic and diuretic drug. Using this product as raw material can greatly reduce the production cost. It is also used as the anti tuberculosis drug, calcium isoniazide pyruvate, hormone synthesis, pyreniumapamote as an insecticide, and also as pesticide raw materials. The tryptophan can be produced by biochemical reaction from pyruvic acid, indole and ammonia, and it can also be used to produce MSG and spices.

Tetraacetylribose is an important intermediate for the production of antiviral Triazole Nucleoside in the pharmaceutical industry. It is mainly used to synthesize broad-spectrum antiviral drug ribavirin. It is also the starting material for the synthesis of nucleoside compounds.

8-Hydroxyquinoline sulfate is a monoplasmic bidentate chelator, which can be used as preservative, disinfectant, insecticide and transcription inhibitor. This product is also a powerful metal chelating agent, which can precipitate a variety of heavy metals and has internal absorption bactericidal activity. It is mainly used in forestry, medicine, chemical industry, cosmetics, etc.

Aromatic amines are a kind of important nitrogen-containing compounds, which are widely used in explosives, dyes and pharmaceutical industries. The synthesis method is generally based on well-known reactions. Simple aromatic amines can be prepared by reduction of nitro compounds or by k-amino substitution of halogenated aromatics. In addition, there are other special preparation methods. in recent years, α- Naphthylamine (also known as 1-naphthylamine) has been well used in dye chemical industry and organic synthesis, especially in the synthesis of axial chiral catalysts.

Shikimic acid is a key precursor for the synthesis of many alkaloids, aromatic acids, indole derivatives and chiral drugs. Shikimic acid has anti-inflammatory and analgesic effects by affecting arachidonic acid metabolism, inhibiting platelet aggregation, inhibiting arteriovenous thrombosis and cerebral thrombosis. It can also be used as an intermediate of antiviral and anticancer drugs. Recently, shikimic acid has been used as the starting material of oseltamivir (the active ingredient of Tamiflu). Oseltamivir is a neuraminidase inhibitor, which can be used to treat and prevent influenza A and influenza B.