Tiotropium bromide, a long-acting (24-hour) anticholinergic bronchodilator for the treatment of chronic obstructive pulmonary disease (COPD), Boehringer Ingelheim and Pfizer jointly launched an inhaled capsule called Spiriva.

N-(Diaminomethylidene)-2-Methyl-4,5-Bis(Methylsulfonyl)Benzamide

CAS:187870-78-6

Molecular Formula:C11H15N3O5S2

Brief Introduction

Rimeporide (EMD-87580) 是一种有效的选择性 Na+/H+ 交换泵 (NHE-1) 抑制剂。

5-[(1S,3S,4R)-7-Azabicyclo[2.2.1]Heptan-3-Yl]-3-Methyl-1,2-Oxazole

CAS:188895-96-7

Molecular Formula:C10H15ClN2O

Brief Introduction

Epiboxidine is a chemical compound which acts as a partial agonist at neural nicotinic acetylcholine receptors, binding to both the α3β4 and the α4β2 subtypes. It was developed as a less toxic analogue of the potent frog-derived alkaloid epibatidine, which is around 200 times stronger than morphine as an analgesic but produces extremely dangerous toxic side effects. Epiboxidine is around one-tenth as potent as epibatidine as an α4β2 agonist, but has around the same potency as an α3β4 agonist. It has only one-tenth of the analgesic power of epibatidine, but is also much less toxic.

Cilengitide

CAS:188968-51-6

Molecular Formula:C27H40N8O7

Alias

More Information

Cyclo(L-Arginylglycyl-L-A-Aspartyl-D-Phenylalanyl-N-Methyl-L-Valyl); Cyclo[-Arg-Gly-Asp-D-Phe-N-Meval-]; Cyclo(Arginyl-Glycyl-Aspartyl-D-Phenylalanyl-N-Methyl-Valyl); Cyclo(Rgdf-N(Me)V-); Cilengitide [Usan:Inn]; Emd-121974; Unii-4Edf46E4Gi; Emd121974

Brief Introduction

Cilengitide is an effective integrin inhibitor that acts on α v β 3 receptors and α v β 5 receptor and IC50 were 4.1 nm and 79 nm, respectively, which were about 10 times more selective than gpIIbIIIa.

Tegaserod Maleate

CAS:189188-57-6

Molecular Formula:C20H27N5O5

Alias

More Information

Zelmac; Zelnorm; Tegaserod (Maleate); Unii-E5Xnt3Rf5A; Hydrazinecarboximidamide, 2-[(5-Methoxy-1H-Indol-3-Yl)Methylene]-N-Pentyl-, (2Z)-2-Butenedioate (1:1); Hydrazinecarboximidamide, 2-((5-Methoxy-1H-Indol-3-Yl)Methylene)-N-Pentyl-, (2Z)-2-Butenedioate (1:1)

Brief Introduction

This product is a partial agonist of 5-HT receptor, which can closely bind with 5 – HT4 receptor, reflecting high affinity; It has moderate affinity for 5-HT1 receptor, but can't bind to 5 – HT3 receptor. Activating 5-HT4 receptor can trigger the release of other neurotransmitters such as calcitonin related gene peptide, stimulate intestinal peristaltic reflex and secretion of intestinal glands, and inhibit visceral sensitivity.

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