4-(5-Methyl-3-Phenylisoxazol-4-Yl)Benzensulfonamide; Kudeq; 4-(4-Sulfamoylphenyl)-5-Methyl-3-Phenyl-Isoxazole; Valdyn; 4-(5-Methyl-3-Phenyl-1,2-Oxazol-4-Yl)Benzenesulfonamide; 4-(5-Methyl-3-Phenyl-4-Isoxazolyl)Benzenesulfonamide; Bextra; 4-[5-Methyl-3-Phenylisoxazol-4-Yl ] Benzenesulfonamide; Valdecoxib(R); [14C]-Valdecoxib

Brief Introduction

Vardixib is not only the key intermediate in the synthesis of parecoxib sodium, but also its main hydrolysate. It is the main impurity in the inspection of related substances of parecoxib sodium. Parecoxib is a non steroidal anti-inflammatory drug. It is an amide precursor (water-soluble precursor) of varcoxib, a highly selective COX-2 inhibitor. After intravenous administration, parecoxib is rapidly hydrolyzed by carboxylesterase to varcoxib, which plays an anti-inflammatory and analgesic role.

2-(4-Methoxyphenyl)-3-[4-(2-Piperidin-1-Ylethoxy)Phenoxy]-1-Benzothiophen-6-Ol

CAS:182133-25-1

Molecular Formula:C28H29NO4S

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Arzoxifene; Unii-E569Wg6E60; Ly 353381

Brief Introduction

Azoxifen is the third generation of selective estrogen receptor modulator developed by Eli Lilly after raloxifene. It has strong antagonistic activity against estrogen receptors in breast, ovary and endometrium; It can also increase the mineral density of lumbar vertebrae and total hip bones of postmenopausal women with normal or low bone mass, mainly for preventing osteoporosis and preventing breast cancer.

Colesevelam Hydrochloride

CAS:182815-44-7

Molecular Formula:C31H67Cl3N4O

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Colesevelam; 2-(Chloromethyl)Oxirane,Prop-2-En-1-Amine,N-Prop-2-Enyldecan-1-Amine,Trimethyl-[6-(Prop-2-Enylamino)Hexyl]Azanium,Chloride,Hydrochloride; Colesevelam Hcl

Brief Introduction

Coleveren hydrochloride is a non absorbable polymer oral drug. It is a new drug for the treatment of hyperlipidemia developed by an American company. It is suitable for the treatment of high serum total cholesterol (TC) or triglyceride (TG). Clinical studies show that patients can reduce the level of cholesterol by taking coleveren alone within 6 ~ 24 weeks, The level of low density lipoprotein cholesterol (LDL-C) is 9 ~ 19%. When combined with other drugs, it can reduce the level of LDL-C by 10 ~ 16%.

5-Bromo-2-Iodopyrimidine

CAS:183438-24-6

Molecular Formula:C4H2BrIN2

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5-Bromo-2-Iodo-Pyrimidine; 5-Bromo-Iodopyrimidine; 2-Iodine-5-Bromopyrimidine; 2-Iodo-5-Bromo-Pyrimidine; 5-Brmo-2-Iodopyrimidine; 2-Bromo-5-Iodopyrimidine; 5-Bromo-2-Iodo-1,3-Diazine

Brief Introduction

5-Bromo-2-iodopyrimidine has been used to prepare pyrazinylpyridine as an effective vascular endothelial growth factor receptor 2 inhibitor. It is also used to prepare novel conformationally constrained glucagon receptor antagonists.

1-[2-[4-(6-Methoxy-2-Phenyl-3,4-Dihydronaphthalen-1-Yl)Phenoxy]Ethyl]Pyrrolidine

CAS:1845-11-0

Molecular Formula:C29H31NO2

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Nafoxidine; Nafoxidine [Inn]; Nafoxidinum [Inn-Latin]; Nafoxidina [Inn-Spanish]

Brief Introduction

Nafoxidine is a triphenylethylene nonsteroidal agent that acts as a partial estrogen antagonist. Nafoxidine competes with endogenous estrogen for binding to specific estrogen receptors. This agent also inhibits angiogenesis in some tissues by blocking the effects of fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF); paradoxically, it may enhance angiogenesis in uterine tissue. Nafoxidine also induces oxidative stress, protein kinase C and calcium signaling.

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