Pharmaceutical Raw Materials

Crotamiton is an enamide resulting from the formal condensation of crotonic acid with N-ethyl-2-methylaniline. A colourless or pale yellow oily liquid, it is used in the treatment of pruritus (itching) by producing a counter-irritation: as it evaporates from the skin, it produces a cooling effect that diverts attention away from the itching. It has also been used as an acaricide in the treatment of scabies, though more effective drugs are usually preferred. It has a role as an antipruritic drug and a scabicide. It is an enamide and a tertiary carboxamide.

Osthol is a substance extracted from the fruit of Fructus Cnidii, an annual herb in Umbelliferae. It has antispasmodic, hypotensive, antiarrhythmic, enhancing immune function and broad-spectrum antibacterial effects. Clinically, it is mainly used to treat male impotence, scrotal wet itching, female vaginal itching, uterine cold infertility, rheumatic arthralgia, scabies wet sore and trichomonal vaginitis. Osthol can also be used as a field insecticide and bactericide. It mainly has contact killing effect, supplemented by gastric toxicity. The drug solution is absorbed into the insect body through the body surface and acts on the insect nervous system, resulting in the non functional contraction of the insect muscle and eventually exhaustion and death. It has a good contact killing effect on a variety of pests such as cabbage worm, tea inchworm, cotton bollworm, beet armyworm and various aphids.

This product is a antihypertensive drug. It can directly act on peripheral blood vessels and reduce blood pressure. At the same time, the blood flow of heart, brain, kidney and viscera increased, accompanied by increased renin secretion and * retention of water and sodium. It is usually combined with other drugs to treat all types of hypertension. Due to the obvious reduction of diastolic blood pressure and increase of blood flow, it is especially suitable for patients with renal insufficiency and high diastolic blood pressure. It can also be used as crosslinking agent and complexing agent of carbonyl polymer compounds and in analytical chemistry.

This product has antibacterial, antifungal, cholesterol lowering and estrogenic effects. It can prevent breast cancer, prostate cancer, colon cancer, improve osteoporosis and improve menopausal symptoms in women.

Proanthocyanidins are a kind of polyphenols, which are condensed from flavan-3-ol monomers. It has strong antioxidant activity and other biological activities, and has been widely used in food, medicine, cosmetics and other fields. Proanthocyanidins have strong antioxidant activity, which is one of the strongest and most effective free radical scavengers ever found by human beings, especially in vivo. The antioxidant activity of proanthocyanidins shows a dose-response relationship, but if it exceeds a certain concentration, its antioxidant activity will decrease with the increase of concentration. Proanthocyanidins have significant killing effect on a variety of tumor cells, and have significant inhibitory effect on a variety of carcinogens in the start-up and cancer promoting stages. Procyanidins can inhibit the growth of cancer cells and induce apoptosis. In addition, it has good anticancer activity for liver cancer, prostate cancer and skin cancer. Procyanidins can reduce the increase of capillary permeability caused by inflammatory mediators such as histamine and bradykinin, reduce the fragility of capillary wall, reduce the tension and permeability of capillary, protect the material transport capacity of capillary, and thus play an anti-inflammatory role. In addition, procyanidins can also inhibit the activity of histamine decarboxylase, limit the role of hyaluronidase, and have a significant effect on a variety of arthritis and gastric and duodenal ulcer.