Pharmaceutical Raw Materials

Pyrrole and its homologues are mainly found in bone tar, but few in coal tar. Pyrrole can be obtained by fractionation of bone tar; Or it can be treated with dilute alkali and then purified by fractionation after acidification. It is a five membered heterocyclic compound with one aza atom and its molecular formula is C4H5N. It is also used in organic synthesis and pharmaceutical industry. Mainly used as polyester fiber spinning solvent. It is also used as metal preservative, curing agent of epoxy resin, catalyst for olefin polymerization and raw material for pharmaceutical industry. It is also used as a photosensitizer.

Pamidronate disodium is a potent osteoclast bone resorption inhibitor. In vitro, it binds closely to hydroxyapatite crystals and inhibits their formation and dissolution. In vivo, it can combine with bone minerals and inhibit osteoclastic bone resorption. Pamidronate can inhibit the attachment of osteoclast precursors to bone and inhibit their transformation into mature and functional osteoclasts. Both in vivo and in vitro, the local and direct anti bone resorption effect of bone bound bisphosphonates is the main mode of action. Experimental studies have shown that pamidronate disodium can inhibit tumor induced osteolysis before or at the same time of tumor cell inoculation or transplantation. Its inhibitory effect on hypercalcemia induced by tumor is shown by the following biochemical changes: the decrease of serum calcium and the secondary reduction of excretion of calcium, phosphate and hydroxyproline in urine.

(REL) - atorvastatin is a relative configuration of atorvastatin. Atorvastatin is an HMG CoA reducing enzyme inhibitor with oral activity, which has the ability to effectively reduce blood lipid. The IC50 values of atorvastatin were 0.39 respectively μ M and 2.39 μ M to inhibit the proliferation and invasion of human sv-smc cells.

Cefetamet Pivoxil hydrochloride is the third generation of oral broad-spectrum cephalosporin antibiotics. It has strong antibacterial activity against gram-positive and Gram-negative bacteria β- Lactamase is stable. Clinically, it is suitable for lower respiratory tract infection, ear, nose, throat infection and urinary system infection caused by sensitive bacteria.

Losartan is a non-peptide angiotensin II antagonist with antihypertensive activity. Upon administration, losartan and its active metabolite selectively and competitively blocks the binding of angiotensin II to the angiotensin I (AT1) receptor. This blocks the vasoconstricting and aldosterone-secreting actions of angiotensin II, leading to a decrease in blood pressure. Angiotensin II, formed from angiotensin I by angiotensin-converting enzyme (ACE), stimulates the adrenal cortex to synthesize and secrete aldosterone, which decreases the excretion of sodium and increases the excretion of potassium. Angiotensin II also acts as a vasoconstrictor in vascular smooth muscle.