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Hubei Biocause Heilen Phamaceutical Co., Ltd.

29 YRS

Hubei, China

CNY 180 Million

139860 m²

500-1000 people

Main Products: Torasemide / Ibuprofen / Dexibuprofen / Ibuprofen Lysinate / Granisetron Hydrochloride / Tropisetron Hydrochloride / Dolasetron Mesylate / Fludarabine Phosphate / Abiraterone / Azacytidine / Clofarabine / Atropine Sulfate / Hyoscyamine Sulfate / Milrinone / Flumazenil / Cladribine / Homatropine Methyl Bromide / Oxaprozin / Balsalazide Sodium

Hubei, China

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Granisetron Hydrochloride / CAS 107007-99-8

OVERVIEW

Packaging

25 KG/Fibre Drum

Lead Time

14-30 days

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DESCRIPTION

Granisetron hydrochloride

English Name: granisetron hydrochloride

CAS number: 107007-99-8

Molecular formula: C18H25ClN4O

MW: 348.87

EINECS number: 634-603-0

Uses: spasmolytic. Antiemetics used for chemo - and radiotherapy induced nausea and vomiting.

Typical Properties

Granisetron hydrochloride is a highly selective 5-HT3 receptor antagonist, which has good preventive and therapeutic effects on nausea and vomiting caused by radiotherapy, chemotherapy and surgery. Radiotherapy, chemotherapy and surgery can cause the release of 5-HT from the intestinal chromaffin cells. 5-HT can activate the 5-HT3 receptor of the central or vagus nerve and cause vomiting reflex. The mechanism of controlling nausea and vomiting is to inhibit the occurrence of nausea and vomiting by antagonizing 5-HT3 receptors in central chemosensory area and peripheral vagus nerve endings. It has high selectivity and no side effects such as extrapyramidal reaction and excessive sedation.

CAS No.

107007-99-8

Formula

C18H25ClN4O

Molecular Mass

348.87000

Exact Mass

348.17200

PSA

50.16000

Logp

3.44920

IUPAC

1-methyl-N-(9-methyl-9-azabicyclo[3.3.1]nonan-3-yl)indazole-3-carboxamide;hydrochloride

SMILES

CN1C2CCCC1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C.Cl

Matter Classification

organic

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