Nitrofurazone(FDA)
Synonymous: 5-Nitro-2-furfurylidene semicarbazone
CAS: 59-87-0
Structure:
Molecular formula: C6H6N4O4
Molecular weight: 198.14
Authentication code: H37022206
Specification:
A: Accord with the drug standard of the Ministry of Health of RRC (1989 edition)
Appearance: Light yellow crystal powder
Assay: 97.0~103.0%
Melting point: 236-240οC
Acidity: 5.5~7.0
Loss on drying: Not more than 0.5%
Residue on ignition: Not more than 0.1%
Sulfate: Not More Than 0.04%
Chloride: Not More Than 0.014%
B: Accord with EP7 edition
Appearance: yellow or brownish yellow crystalline powder
Assay: 97.0~103.0%
Loss on drying: Not more than 0.5%
Residue on ignition: Not more than 0.1%
Acidity: 5.5~7.0
Nitrofurfural Diacetate: Not more than 0.5%
5-nitro-2-furfuraldazine: Not more than 0.5%
C: Accord with USP35 edition
Appearance: yellow or brownish yellow crystalline powder
Loss on drying: Not more than 0.5%
Residue on ignition: Not more than 0.1%
Acidity: 5.5~7.0
Assay: 98.0~102.0%
5-nitro-2-furfuraldazine: Not more than 0.5%
Related substance: Not more than2.0%
Acetic acid: Not more than 1000ppm
Use: disinfectant and antiseptic used for local or surface sterilization.
Nitrofurazone appears as odorless pale yellow needles or yellow powder. pH (saturated aqueous solution) 6.0 - 6.5. Alkaline solutions are dark orange. (NTP, 1992)
Nitrofurazone is a semicarbazone resulting from the formal condensation of semicarbazide with 5-nitrofuraldehyde. A broad spectrum antibacterial drug, although with little activity against Pseudomonas species, it is used as a local application for burns, ulcers, wounds and skin infections. It has a role as an antibacterial drug. It is a semicarbazone and a nitrofuran antibiotic.
A topical anti-infective agent effective against gram-negative and gram-positive bacteria. It is used for superficial WOUNDS AND INJURIES and skin infections. Nitrofurazone has also been administered orally in the treatment of TRYPANOSOMIASIS.
IUPAC
[(E)-(5-nitrofuran-2-yl)methylideneamino]urea
SMILES
C1=C(OC(=C1)[N+](=O)[O-])/C=N/NC(=O)N