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Shanghai Xudong Haipu Nantong Pharmaceutical Co.,Ltd.

32 YRS

Jiangsu, China

CNY 45.9 Million

14652 m²

50-100 people

Main Products: Flucytosine / Urea / Fluorouracil / 4,6-Dichloro-5-Fluoropyrimidine / 2-Methoxy-5-Fluorouracil / 2-Ethoxy-5-Fluoro-1H-Pyrimidin-4-One

Jiangsu, China

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Flucytosine / CAS 2022-85-7

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Packaging

25 KG/Fibre Drum

Lead Time

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DESCRIPTION

Flucytosine

English Name: Flucytosine

CAS No.: 2022-85-7

Molecular formula: C4H4FN3O

Molecular weight: 129.09

EINECS No.: 217-968-7

Chemical properties: white or off-white crystalline powder, odorless or slightly odorless. Slightly soluble in water, 1.2% (20 ℃) in water, slightly soluble in ethanol; Almost insoluble in chloroform and ether; Soluble in dilute hydrochloric acid or dilute sodium hydroxide solution. It is stable at room temperature, precipitates and crystallizes when it is cold, and partially transforms into 5-fluorouracil when it is hot.

Application: antifungal drug. It is mainly used for skin mucosal candidiasis, Candida endocarditis, Candida arthritis, cryptococcal meningitis and chromomycosis. The hemogram should be checked regularly during medication. Use with caution in patients with liver and renal insufficiency, hematopathy and pregnant women; It is forbidden for patients with severe renal insufficiency.

Typical Properties

5-fluorocytosine (5-FC), also known as 5-fluorocytosine, 5-fluorocytidine, anjezhi, and anlapen, is a white or quasi white crystalline powder. The inhibitory effect of 5-fluorocytosine on fungi is due to its entering into the cells of sensitive fungi, and under the action of cytosine deaminase, 5-fluorouracil, an anti metabolite, is formed. The latter is converted to 5-fluorouracil-2-deoxyriboside, which inhibits thymidine synthase, blocks the conversion of 5-fluorouracil-2-deoxyriboside to thymidine, and affects DNA synthesis. It has a good inhibitory effect on Candida, Cryptococcus and hyphomycetes, and also has an effect on some Aspergillus, as well as mycospores and bottle fungi which cause skin fungal diseases.

CAS No.

2022-85-7

Formula

C4H4FN3O

Molecular Mass

129.09200

Exact Mass

129.03400

PSA

71.77000

Logp

0.07240

IUPAC

6-amino-5-fluoro-1H-pyrimidin-2-one

SMILES

C1=NC(=O)NC(=C1F)N

Matter Classification

organic

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