Our Advantages
- Complete qualifications: multiple raw materials have passed GMP certification; DMF registration in India and Uzbekistan; EU REACH registration certificate, HALAL halal certification, and KOSHER clean food certification.
- Stable quality: The company has passed the ISO9001 certification, achieving full process control from product design and development, raw material procurement, process control to product sales.
- Strong R&D strength: The company attaches great importance to investing in product development and improving its overall R&D strength.
Properties: white or off white crystalline powder
Purity (HClO4): ≥ 98.5%
Specifications
Items | Requirements |
Description | White or almost white crystalline powder. |
Identification | 1. Fade when adding bromine liquid |
2. Max absorption at 286nm; absorbance of about 0.71 |
3. The infrared absorption spectrum is concordant with the reference standard |
Clarity and color | Clear and colorless |
Acidity and alkalinity | 5.5~7.5 |
Loss on drying | ≤0.5% |
Residue on ignition | ≤0.2% |
Heavy Metals | ≤0.002% |
Assay(HCLO4) | ≥98.5% |
Related impurities | Fluorouracil≤0.2% |
Other impurity≤1.0% |
Storage conditions: sealed, cool and dry
Uses: pharmaceutical raw materials - antifungal drugs, bacteriostatic agents
Pharmaceutical raw material intermediate
Applications:
- Antifungal drugs:
5-fluorocytosine can be used as an antifungal drug, especially with antibacterial activity against some fungal infections. It is often used to treat infectious diseases caused by fungi such as Candida and Cryptococcus.
- Conversion to antitumor drugs:
5-fluorocytosine can be metabolized into 5-fluorouracil (5-FU), which is a commonly used antitumor drug. In vivo, after 5-fluorocytosine is converted into 5-FU, it can exert antitumor activity by affecting nucleic acid synthesis, inhibiting tumor cell proliferation and inducing apoptosis.
Upstream product: cytosine
Downstream product: Lamivudine; Capecitabine; Enqutabin et al
5-fluorocytosine (5-FC), also known as 5-fluorocytosine, 5-fluorocytidine, anjezhi, and anlapen, is a white or quasi white crystalline powder. The inhibitory effect of 5-fluorocytosine on fungi is due to its entering into the cells of sensitive fungi, and under the action of cytosine deaminase, 5-fluorouracil, an anti metabolite, is formed. The latter is converted to 5-fluorouracil-2-deoxyriboside, which inhibits thymidine synthase, blocks the conversion of 5-fluorouracil-2-deoxyriboside to thymidine, and affects DNA synthesis. It has a good inhibitory effect on Candida, Cryptococcus and hyphomycetes, and also has an effect on some Aspergillus, as well as mycospores and bottle fungi which cause skin fungal diseases.
IUPAC
6-amino-5-fluoro-1H-pyrimidin-2-one
SMILES
C1=NC(=O)NC(=C1F)N