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Shanghai Jinhe BIO-PHARMACEUTICAL Co., Ltd.

22 YRS

Shanghai, China

CNY 3.4 Million

19980 m²

100-500 people

Main Products: Paclitaxel / Docetaxel / Docetaxel Trihydrate / Cabazitaxel / 10-Deacetylbaccatin III / Baccatine III

Shanghai, China

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Docetaxel Trihydrate / CAS 148408-66-6

OVERVIEW

Packaging

5 KG/BOTTLE

Lead Time

14-30 days

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DESCRIPTION

Docetaxel Trihydrate

Product Information
Product Name	Docetaxel Trihydrate
Molecular Formula	C₄₃H₅₃NO₁₄.3H₂O (861.9)
Cas No.	148408-66-6
Analysis	Standard
Assay(W/W)	98.0-102.0%
Purity (HPLC)	≥99.5%
Quality standard	EP
Physical Control
Appearance	White or almost white crystalline powder
Identification	Conforms
Specific Optical Rotation	-40°～-47°
Water	5.0%-7.0%
Solubility in Polysorbate-80	45.0mg/ml Min
Chemical Control
Residue of solvents	Complies with ICH requirement
Residue on Ignition	≤0.2%
Bacteria Endotoxins	NMT0.4 EU/mg
Heavy Metal	NMT20ppm
Chromatographic Impurities
Highest Individual Impurity	NMT0.1%
Unknown Inpurity	NMT0.1%
Total Impurity	NMT0.5%
Microbiological Control
Total Aerobic Microbial Count	NMT 100cfu/g
S.Aureus & Aeruginosa	Negative
Salmonella & E.Coil	Negative
Storage
Store at 2-8°C, In well closed containers and protect from light and moisture.

Typical Properties

Paclitaxel trihydrate can be used as organic synthesis intermediate and pharmaceutical intermediate. It is mainly used in laboratory research and development process and chemical pharmaceutical synthesis process. It is mainly used as synthetic intermediate of anticancer drugs.

CAS No.

148408-66-6

Formula

C43H53NO14.3H2O

Molecular Mass

861.929

Exact Mass

861.37800

PSA

252.14000

Logp

3.45760

IUPAC

[(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-acetyloxy-1,9,12-trihydroxy-15-[(2R,3S)-2-hydroxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoyl]oxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate;trihydrate

SMILES

CC1=C2[CH](C(=O)[C]3([CH](C[CH]4[C]([CH]3[CH]([C](C2(C)C)(C[CH]1OC(=O)[CH]([CH](C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O.O.O.O

Matter Classification

organic

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