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Jiangsu Simcere Pharmaceutical Co., Ltd.

29 YRS

Jiangsu, China

CNY 568.8 Million

219780 m²

Over 1000 people

Main Products: Posaconazole / Diosmectite / Zanamivir / Palonosetron Hydrochloride / Pemetrexed Disodium / Bendamustine HCl / Palbociclib / Cabozantinib Malate / Ibrutinib / Edoxaban(Tosylate Monohydrate) / Bedaquiline Fumarate / Apremilast

Jiangsu, China

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Posaconazole / CAS 171228-49-2

OVERVIEW

Packaging

25 KG/Fibre Drum

Lead Time

14-30 days

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DESCRIPTION

posaconazole

Product introduction:

Posaconazole is a derivative of itraconazole. It was the second generation of triazole antifungal drugs listed in FDA in 2006. The trade name is noxafil, and phase III clinical trial is currently under way. The pharmacological effect is the same as that of azole drugs, but compared with itraconazole, it has a stronger inhibitory effect on sterol C14 demethylation, especially on Aspergillus.

Indication:

This product is suitable for mycoemia caused by Candida and Cryptococcus fungi, respiratory, digestive and urinary tract mycosis, peritonitis, meningitis, etc.

Chinese Name：	泊沙康唑
Synonymous：	Pcz
CAS：	171228-49-2
Molecular formula：	C₃₇H₄₂F₂N₈O₄
Molecular weight：	700.78
Appearance	White Solid
Storage	Sealed in dry ；moisture-proof

Typical Properties

Posaconazole is used in patients with invasive aspergillosis refractory to amphotericin B or itraconazole or in patients who cannot tolerate treatment with these agents.It is clinically useful in the treatment of aspergillosis, zygomycosis and sickle cell disease, but also in the treatment of some fluconazole resistant Candida infections.

CAS No.

171228-49-2

Formula

C37H42F2N8O4

Molecular Mass

700.77700

Exact Mass

700.33000

PSA

115.70000

Logp

4.70320

IUPAC

4-[4-[4-[4-[[(3R,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one

SMILES

CCC(C(C)O)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OCC5CC(OC5)(CN6C=NC=N6)C7=C(C=C(C=C7)F)F

Matter Classification

organic

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