Bacitracin Zinc

1、Nomenclature

English name： Bacitracin Zinc

2、Stuctural formula

Molecular

Structure

结构式

Molecular formula：C66H103N17O16SZn

Molecular weight：1486.07

CAS号CAS No.：1405-89-6

3、Mechanism and clinical use:

Bacitracin Zinc is used in medicine as a polypeptide antibiotic. Bacitracin zinc has bactericidal action for Gram-positive bacteria. The mechanism of action: act on cell wall, bind with cell wall of sensitive bacteria, damage cell wall integrity, and give rise to outflow of important materials in cell.

It can effectively inhibit Gram-positive bacteria and some Gram-negative bacteria. The rate of bacterial resistance to bacteria is slow. There is no cross resistance with other antibiotics. It can promote the growth of livestock and poultry, and improve feed conversion rate.

On June 2019, API Bacitracin Zinc was granted “written confirmation for active substance exported to EU”.

4、Packaging size specification

Inner package: single-layer polyethylene bag and aluminum foil bag.

Outer package: fiber drum.

Packaging size: 10 Kg/drum

Properties

Bacitracin zinc is a kind of polypeptide antibiotic, which has bactericidal effect on Gram-positive bacteria. Its mechanism is mainly to inhibit the synthesis of bacterial wall, and can also bind with the cell membrane of sensitive bacteria, damage the integrity of cell membrane, leading to the outflow of important substances in cells. It can effectively inhibit Gram-positive bacteria and some Gram-negative bacteria; Bacterial resistance to bacitracin was slow, and there was no cross resistance with other antibiotics. Promote the growth of livestock and poultry, improve feed conversion rate. Bacitracin zinc was hardly absorbed by oral administration, and most of it was excreted with feces within 2 days. Zinc bacitracin has synergistic antibacterial effect with penicillin, streptomycin, neomycin, chlortetracycline and colistin. This product has incompatibility with olaquindox, kitasamycin, virginiamycin and enramycin. For gram positive bacteria and Penicillium resistant.

CAS No.

1405-89-6

Formula

C66H101N17O16SZn

Molecular Mass

1486.06

Exact Mass

1483.66

PSA

561.83000

Logp

1.05220