Sodium Fusidate
1、Nomenclature
English name:Sodium Fusidate
2、Structural formula
Molecular Structure | |
Molecular formula:C31H47NaO6
Molecular weight:538.70
CAS号CAS No.:751-94-0
3、Mechanism and clinical use:
Sodium Fusidate is manufactured by salification reaction of sodium hydroxide and Fusidic Acid, the latter is extracted from the fermentation broth of Fusidium coccineum. It is a narrow-spectrum, high-efficiency and anti gram-positive bacteria antibiotic widely used in foreign countries.
Sodium Fusidate produces antibacterial effect by inhibiting bacteria protein synthesis. Sodium Fusidate keeps relatively strong antibacterial activity and very low resistance to most staphylococcus strain, more and more receives people’s attention, and becomes new selection of anti resistant staphylococcus aureus (MRSA).
Sodium Fusidate is mainly used for treatment of infections incurred by all kinds of sensitive bacteria, especially by staphylococcus. Its toxicity is very low, and it has no cross anaphylaxis with other antibacterial drugs. It can be used to patients who have taboo to other antibiotics, such as penicillin.
4、Packaging size specification
Inner package: single-layer polyethylene bag and aluminum foil bag.
Outer package: fiber drum.
Packaging size: 15 Kg/drum
Sodium sildenate, also known as sodium fusaric acid and sodium fusillate, is a narrow-spectrum antibiotic with steroidal skeleton. It is a derivative of fusidic acid. It is white crystal or crystalline powder, odorless, bitter and slightly hygroscopic. It is easily soluble in water and ethanol, slightly soluble in chloroform and insoluble in copper propionate, ether and benzene. It was successfully developed by Leo pharmaceutical company of Denmark for the first time. Its trade name is ristine. It has strong tissue permeability. It is mainly metabolized in the liver and excreted by bile without being excreted by the kidney. It has low toxicity. It has bactericidal effect by inhibiting bacterial protein synthesis. It has good antibacterial effect on Gram-positive bacteria and good drug resistance. At the same time, it is resistant to penicillin Methicillin and other antibiotic resistant strains are still sensitive to this product, and there is no cross resistance between sodium fuxidate and other antibiotics used clinically.
IUPAC
sodium;(2Z)-2-[(3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-16-acetyloxy-3,11-dihydroxy-4,8,10,14-tetramethyl-2,3,4,5,6,7,9,11,12,13,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ylidene]-6-methylhept-5-enoate
Matter Classification
organic
Boiling Point
635.6ºC at 760 mmHg
Appearance
White crystalline powder