Nitrofurantoin

Chemical name: 1-{[(5-nitrofuran-2-yl)methylidene]amino}imidazolidine-2,4-dione

CAS: 67-20-9

Structure:

Molecular formula: C₈H₆N₄O₅

Molecular weight: 238.16

Authentication code: H37022205

Specification:

A: Accord with China Pharmacopoeia 2010 edition

Appearance: Yellow crystal powder

Assay: 98.0~102.0%

Loss on drying: Not more than 1.0%

Reidue on ignition: Not more than 0.1%

Acidity: 5.5~7.0

Related substances: ≤1%

Nitrofurazone: ≤ 0.01%

B: Accord with Europe Pharmacopoeia (EP7) edition

Appearance: A yellow crystalline powder or yellow crystals

Assay: 98.0~102.0%

Loss on drying: Not more than 1.0%

Sulphated ash: Not more than 0.1%

Related substance: Not more than 1.0%

C: Accord with United States Pharmacopoeia 35 edition

Appearance: A lemon-yellow crystalline powder.

Assay: 98.0~102.0%

Loss on drying: Not more than 1.0%

Limit of Nitrofurfural Diacetate: not more than 1.0%

Limit of Nitrofurazone: not more than 0.01%

Application: Used for urinary tract infections resulted by sensitive bacteria, like pyelonephritis, urinary tract infection, cystitis and prostatitis.