Docetaxel Anhydrous 99.5%

Product Information
Product Name	Docetaxel Anhydrous 99.5%
Molecular Formula	C₄₃H₅₃NO₁₄(807.88)
Cas No.	114977-28-5
Quality standard	EP
Analysis	Standard
Assay(W/W)	98.0-102.0%
Purity(HPLC)	≥99.5%
Physical Control
Appearance	White crystalline powder
Identification	Conforms
Specific Optical Rotation	-40°～-47°
Water	≤3.0%
Chemical Control
Residue of solvents	Complies with ICH requirement
Residue on Ignition	NMT0.2%
Bacteria Endotoxins	0.4EU/MG
Heavy Metal	NMT20ppm
Chromatographic Impurities
Highest Individual Impurity	NMT0.1%
Unknown Impurity	NMT0.1%
Total Impurity	NMT0.5%
Microbiological Control
Total Aerobic Microbial Count	NMT 100cfu/g
S.Aureus & Aeruginosa	Negative
Salmonella & E.Coil	Negative
Storage
Store at 2-8°C, In well closed containers and protect from light and moisture.

Properties

Docetaxel is an anticancer and antitumor drug. It can be used to study antibiotics, cell biology, cell signal transduction, neuroscience, apoptosis and cell cycle. Docetaxel is also used to study hair loss caused by docetaxel chemotherapy, prevention and treatment of non-small cell lung cancer in patients with contraindicated standard chemotherapy.

CAS No.

114977-28-5

Formula

C43H53NO14

Molecular Mass

807.8790

Exact Mass

807.34700

PSA

224.45000

Logp

3.65050

IUPAC

[(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-acetyloxy-1,9,12-trihydroxy-15-[(2R,3S)-2-hydroxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoyl]oxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate

Matter Classification

organic

Category

Melting Point

186-192 °C

Density

1.37 g/cm3

Boiling Point

900.5ºC

Flash Point

498.4ºC

Appearance