Paclitaxel (Semi-Synthetic)

English Name: Paclitaxel

CAS No.: 33069-62-4

Molecular formula: C47H51NO14

Molecular weight: 853.92

EINECS No.: 608-826-9

Melting point: 213 ° C (Dec.) (lit.)

Specific rotation: D20 - 49 ° (methanol)

Boiling point: 774.66 ° C (rough estimate)

Density: 0.200

Refractive index: - 49 ° (C = 1, MeOH)

Flash point: 9 ℃

Overview: Paclitaxel is a monomer diterpenoid extracted from the bark of Natural Plant Taxus. It is a complex secondary metabolite and the only drug known to promote microtubule polymerization and stabilize polymerized microtubules. Isotope tracing showed that paclitaxel only bound to polymerized microtubules and did not react with unpolymerized tubulin dimers. After contacting paclitaxel, cells will accumulate a large number of microtubules in cells. The accumulation of these microtubules interferes with various functions of cells, especially stops cell division in mitotic stage and blocks normal cell division. Paclitaxel is mainly used in ovarian cancer and breast cancer through the second - and third clinical study. It also has some effect on lung cancer, colorectal cancer, melanoma, head and neck cancer, lymphoma and brain tumor.