Dantrolene Sodium

Synonymous: 1 - {[5 - (4-nitrophenyl) - 2-furanyl] methylene} amino-2,4-imidazolidinedione sodium salt 3.5 crystal water

Structure:

Molecular formula:C₁₄H₉N₄NaO₅·3.5H₂O

Molecular weight: 399.29

Properties: This product is orange yellow to dark orange crystal powder, containing 3.5 crystal water. It is soluble in alkali solution, more soluble in propylene glycol, less soluble in methanol, less soluble in ethanol, very insoluble in water or glacial acetic acid, and almost insoluble in acetone, tetrahydrofuran or ether.

Quality standard: enterprise standard (usp32 Pharmacopoeia)

Quality index:

Heavy metal: ≤ 20ppm

Moisture: 14.5 ~ 17.0%

Impurity A: ≤ 0.15%

Impurity B: ≤ 0.40%

Impurity C: ≤ 0.15%

Chloride: ≤ 0.02%

Sodium content: 5.5 ~ 6.0%

Content: 98.0% ~ 102.0% (calculated by dry product, including C₁₄H₉N₄NaO₅)

Single maximum unknown impurity: ≤ 0.10%

Total impurities: ≤ 0.60%

Functions and uses: as a muscle relaxant, this product is used to treat the following diseases with spastic paralysis: sequelae of cerebrovascular disorders, cerebral palsy, traumatic sequelae (head trauma and spinal cord injury), cervical spondylosis, ossification of ligaments, spinocerebellar degeneration, spastic spinal cord paralysis, myelitis, spinal atrophic lateral sclerosis and multiple sclerosis.