Cytarabine is a kind of purine nucleoside antiviral drug which is extracted from Streptomyces culture medium and synthesized by chemical method. It is slightly soluble in water, and its monophosphate is easily soluble in water. It can inhibit HSV1 and HSV2, hepatitis B virus, varicella zoster virus and cytomegalovirus, but has no effect on smallpox virus, adenovirus, other DNA or RNA viruses, bacteria and fungi. At present, the exact mechanism of cytosine arabinoside antiviral has not been fully elucidated, which is mainly related to the inhibition of virus replication. Drugs and their metabolites block the synthesis of viral DNA by inhibiting viral DNA polymerase, while drugs only penetrate into viral DNA molecules in a very small amount. Cytarabine is also one of the most effective drugs for the treatment of acute non lymphocytic myeloid leukemia in China.
Manufacturing
