Chemical name: 9-alpha-fluoro-11-beta,17-alpha,21-trihydroxy-16-alpha-methylpregna-1,4-diene-3,20-dione
Category: adrenocortical hormone APIs
Specifications: 1kg/tin
Standard: CP/BP/USP/EP
Approval number: Chinese Drug Approval Number H20053754
Quality standard: Chinese Pharmacopoeia 2015 edition
Properties: white or off-white crystalline powder.
Identification: positive reaction
Melting point: 255~264°C.
Specific rotation: +72° to +80°
Absorbance: 380~410
Related substances: maximum impurity≤1.0%, total impurities≤2.0%
Drying loss: ≤0.5%
Residue on ignition: ≤0.2%
Microbial limit: total amount of aerobe≤103cfu/g; mould and yeast≤102cfu/g; no escherichia coli can be detected.
Content: C22H29FO5 in dry product is 97.0%~102.0%.
Storage: the product should be tightly sealed and kept in shading place.
Chemical structural formula:
Properties
Summary
Dexamethasone is a synthetic corticosteroid that can be used to treat multiple symptoms, including rheumatic diseases, certain skin diseases, severe allergies, asthma, chronic obstructive pulmonary disease, hypersensitivity laryngitis, brain edema, and may be used in combination with antibiotics for tuberculosis patients. For patients with adrenal insufficiency, they should take drugs with corticosteroid, such as energetic ingots, etc. Dexamethasone can improve prognosis in preterm infants. The product usually starts to play its effect within one day, and the effect can be maintained for about three days. Long term use of dexamethasone can lead to candidiasis, bone loss, cataract, easy to stasis, or muscle fatigue. The pregnancy grade of this product in the United States is grade C, and the effect of the drug use should be evaluated to be greater than that of the side effects; Australia was rated a, indicating that the product is commonly used in pregnant women and there is no evidence that it will cause harm to the fetus. This medicine is not allowed during lactation. This product has the effect of anti-inflammatory and immunosuppression. Dexamethasone was first synthesized in 1957 and is listed in the list of who basic drugs standards, which is one of the essential drugs for basic public health system. The product is cheap and usually costs less than $25 a month in the United States. In India, preterm treatment costs only $0.5 a time. Dexamethasone is easily available in most countries.