Chemical name: (11beta,16alpha)-9-fluoro-11,21-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl acetate
Category: adrenocortical hormone APIs
Specifications: 1kg/tin
Standard: CP/BP/USP/EP
Approval number: Chinese Drug Approval Number H20053752
Quality standard: Chinese Pharmacopoeia 2015 edition
Properties: white or off-white crystal or crystalline powder. No odor, has a little bitter taste.
Identification: positive reaction
Melting point: 223℃~233℃.
Specific rotation: +82º~+88º
Absorbance: 343~371.
Related substances：maximum impurity≤0.5％, total impurities≤1.0%.
Drying loss: ≤0.5%
Residue on ignition: ≤0.1%
Microbial limit: total amount of aerobe≤103cfu/g; mould and yeast≤102cfu/g; no escherichia coli can be detected.
Content: C24H31FO6 content in dry product is 97.0%~102.0%.
Storage: the product should be tightly sealed and kept in shading place.
Chemical structural formula:
Properties
Summary
Dexamethasone acetate, an adrenocorticotropic hormone, has anti-inflammatory, antiallergic, and antishock effects that are more pronounced than prednisone, whereas it has very mild effects on water and sodium retention and promotion of potassium excretion, and stronger pituitary adrenal suppression. Dexamethasone acetate injection is mainly used in the clinic for allergic versus autoimmune inflammatory diseases. Such as connective tissue diseases, rheumatoid arthritis, severe bronchial asthma, dermatitis and other allergic diseases, ulcerative colitis, acute leukemia, malignant lymphoma and so on.
Manufacturing
